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Titolo:
AGE-RELATED DECLINE IN MRI VOLUMES OF TEMPORAL-LOBE GRAY-MATTER BUT NOT HIPPOCAMPUS
Autore:
SULLIVAN EV; MARSH L; MATHALON DH; LIM KO; PFEFFERBAUM A;
Indirizzi:
VET AFFAIRS HLTH CARE SYST,PSYCHIAT SERV 116A3,3801 MIRANDA AVE PALO ALTO CA 94304 STANFORD UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI STANFORD CA 94305
Titolo Testata:
Neurobiology of aging
fascicolo: 4, volume: 16, anno: 1995,
pagine: 591 - 606
SICI:
0197-4580(1995)16:4<591:ADIMVO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; CHRONIC-ALCOHOLISM; DENDRITIC EXTENT; CT SCANS; BRAIN; MEMORY; SCHIZOPHRENIA; IMAGES;
Keywords:
HIPPOCAMPUS; TEMPORAL LOBES; AGING; MEMORY; GRAY MATTER; WHITE MATTER; VENTRICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
E.V. Sullivan et al., "AGE-RELATED DECLINE IN MRI VOLUMES OF TEMPORAL-LOBE GRAY-MATTER BUT NOT HIPPOCAMPUS", Neurobiology of aging, 16(4), 1995, pp. 591-606

Abstract

The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly correlated with age. By contrast, left and right temporal lobe gray matter volumes, exclusive of the hippocampal measures, each decreased with age (p < 0.01). Volumes of temporal lobe sulcal CSF and the ventricular system (temporal horns andlateral and third ventricles) significantly increased with age. Measures of verbal and nonverbal working memory showed age-related declinesand were related to enlargement of the three ventricular regions, which may be indicative of age-related atrophy of the adjacent cortex butnot the hippocampus, at least up to age 70 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:53:39