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Titolo:
CORTICOTROPIN-RELEASING FACTOR MODULATION OF THE ULTRASONIC VOCALIZATION RATE OF ISOLATED RAT PUPS
Autore:
HARVEY AT; HENNESSY MB;
Indirizzi:
INST PSYCHIAT RES,1100 N ST FRANCIS,SUITE 200 WICHITA KS 67214 WRIGHT STATE UNIV,DEPT PSYCHOL DAYTON OH 45435
Titolo Testata:
Developmental brain research
fascicolo: 2, volume: 87, anno: 1995,
pagine: 125 - 134
SICI:
0165-3806(1995)87:2<125:CFMOTU>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL-RESPONSES; ISOLATION CALLS; FACTOR CRF; STRESS; DISTRESS; ONTOGENY; HORMONE; SYSTEM;
Keywords:
CORTICOTROPIN-RELEASING FACTOR; RAT; INFANT; ULTRASONIC VOCALIZATION; MATERNAL SEPARATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.T. Harvey e M.B. Hennessy, "CORTICOTROPIN-RELEASING FACTOR MODULATION OF THE ULTRASONIC VOCALIZATION RATE OF ISOLATED RAT PUPS", Developmental brain research, 87(2), 1995, pp. 125-134

Abstract

The effect of corticotropin-releasing factor (CRF) on ultrasonic vocalizations (USVs) and other behaviors of isolated rat pups was examinedat 5/6-, 9/10-, and 13/14-days. The hypothesis tested was that central CRF affects USV rate biphasically: as endogenous CRF increases from low basal levels it initiates USV production, but at higher levels CRFdiminishes USV production. As predicted, the largest doses of CRF (0.1 and 1 mu g) and of its antagonist alpha-helical CRF(9-41) (aH-CRF; 20 mu g) administered intracerebroventricularly (ICV) reduced USV rate compared to saline treatment during a 2-min isolation at ambient temperature in pups of all ages. Other behaviors were either unaffected or increased by drug treatment. Effects were not attributable to sedationor to a change in core temperature. Peripheral administration of 1 mug CRF or 20 mu g aH-CRF had no effect. When isolation occurred in a heated chamber containing soiled bedding from the home cage to minimizebaseline USV rate, ICV-CRF (0.001, 0.01, 0.1, or 1 mu g) did not enhance the rate. The quieting ability of aH-CRF is evidence that central endogenous CRF enhances the rate of ongoing USVs during brief isolation; the quieting ability of CRF suggests that this peptide may also be responsible for the reduction in USV rate that normally occurs during more protracted isolation. However, CRF alone is not sufficient to induce vocalizing in quiet pups.

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Documento generato il 17/01/20 alle ore 20:22:28