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Titolo:
NEURODEVELOPMENTAL ANIMAL-MODELS OF SCHIZOPHRENIA
Autore:
LILLRANK SM; LIPSKA BK; WEINBERGER DR;
Indirizzi:
NIMH,NEUROSCI CTR ST ELIZABETHS,INTRAMURAL RES PROGRAM,CLIN BRAIN DISORDERS BRANCH WASHINGTON DC 20032
Titolo Testata:
Clinical neuroscience
fascicolo: 2, volume: 3, anno: 1995,
pagine: 98 - 104
SICI:
1065-6766(1995)3:2<98:NAOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOMORPHINE-INDUCED STEREOTYPY; INDUCED LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX; HIPPOCAMPAL DAMAGE; DOPAMINE-RECEPTORS; NUCLEUS-ACCUMBENS; PRENATAL EXPOSURE; MONOZYGOTIC TWINS; RATS; LESIONS;
Keywords:
SCHIZOPHRENIA; NEURODEVELOPMENT; ANIMAL MODEL; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Lillrank et al., "NEURODEVELOPMENTAL ANIMAL-MODELS OF SCHIZOPHRENIA", Clinical neuroscience, 3(2), 1995, pp. 98-104

Abstract

One difficulty in reproducing the core neurobiological features of schizophrenia in experimental animals is that most neurobiological data about the illness are inconclusive: neither the inducing conditions nor the neurobiological mechanisms have been made clear. We review the advantages and limitations of animal models of schizophrenia based on neurodevelopmental hypotheses that implicate early, probably prenatal age, as the time at which the fundamental disease process occurs. Thesemodels, although principally founded on circumstantial clinical evidence of early developmental neuropathology, seem to reproduce a surprisingly broad spectrum of prominent neurobiological aspects of the disorder, and may help explain mechanisms that underlie the pathophysiologyof this illness. In particular, the model based on neonatal excitotoxic hippocampal damage has provided data indicating the neurobiologicalplausibility of the notion that a developmental cortical defect has adelayed effect on cortical function and dopamine regulation (i.e., the neurodevelopmental hypothesis). (C) 1995 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 00:26:47