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Titolo:
EVIDENCE FOR ALTERED SELENIUM STATUS IN PREGNANT-WOMEN WITH DIABETES
Autore:
FARHAT A; PICCIANO MF; LAMMIKEEFE CJ; DESILVA HN;
Indirizzi:
PENN STATE UNIV,DEPT NUTR,126 HENDERSON BLDG S UNIVERSITY PK PA 16802 PENN STATE UNIV,DEPT NUTR UNIVERSITY PK PA 16802 UNIV CONNECTICUT,DEPT NUTR SCI STORRS CT 06269 UNIV CONNECTICUT,DEPT PAEDIAT & FAMILY MED STORRS CT 06269 ST FRANCIS HOSP & MED CTR HARTFORD CT 00000
Titolo Testata:
The Journal of trace elements in experimental medicine
fascicolo: 1, volume: 8, anno: 1995,
pagine: 29 - 39
SICI:
0896-548X(1995)8:1<29:EFASSI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE-ACTIVITY; RAT; PLASMA; ERYTHROCYTES; LACTATION; SELENATE;
Keywords:
GLUTATHIONE PEROXIDASE; GESTATIONAL DIABETES; INSULIN DEPENDENT DIABETES; CORD PLASMA; MATERNAL PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Farhat et al., "EVIDENCE FOR ALTERED SELENIUM STATUS IN PREGNANT-WOMEN WITH DIABETES", The Journal of trace elements in experimental medicine, 8(1), 1995, pp. 29-39

Abstract

The possible relationship between selenium status and gestational diabetes was investigated. Selenium concentration in maternal and umbilical cord plasma and glutathione peroxidase activity (Se-GPx) in maternal plasma were measured in 40 pregnant women. Subjects included pregnant women with gestational diabetes (GD, n = 12), insulin dependent diabetes (ID, n = 11), and controls (ND, n = 17). Both groups of pregnant women with diabetes delivered early compared to control women (GD, 37.2; ID, 35.5 and ND, 39.7 wk; P < 0.0001). Values for maternal plasma selenium and Se-GPx in both the GD (1.26 mu mol/L and 1.55 mU/mg protein, respectively) and ID (1.37 mu mol/L and 1.81 mU/mg protein, respectively) groups were, respectively, about 55 and 65% lower compared to those of the ND group (2.04 mu mol/L; P < 0.0001 and 2.77 mU/mg protein; P < 0.0001, respectively). Gestational age at delivery did not influence indices of selenium status in the three groups. Cord plasma selenium concentration did not differ among the three groups (GD, 1.25; ID,1.37 and ND, 1.69 nmol/L; P < 0.09). Maternal plasma selenium was positively correlated with maternal plasma Se-GPx (r = 0.79; P < 0.0001). Cord plasma selenium concentration was 17% lower compared to maternalplasma in the control group (P < 0.05). Results show that diabetes, whether long standing or of gestational origin, alters indices of maternal selenium metabolism during pregnancy. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:26:55