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Titolo:
DIFFERENT CHROMOSOMAL LOCALIZATION OF THE CLCN4 GENE IN MUS-SPRETUS AND C57BL 6J MICE/
Autore:
RUGARLI EI; ADLER DA; BORSANI G; TSUCHIYA K; FRANCO B; HAUGE X; DISTECHE C; CHAPMAN V; BALLABIO A;
Indirizzi:
TELETHON INST GENET & MED,SAN RAFFAELE BIOMED SCI PK MILAN ITALY TELETHON INST GENET & MED MILAN ITALY UNIV WASHINGTON,DEPT PATHOL SEATTLE WA 98195 BAYLOR COLL MED,DEPT MOLEC & HUMAN GENET HOUSTON TX 77030 ROSWELL PK CANC INST,DEPT MOLEC & CELL BIOL BUFFALO NY 14263 UNIV SIENA,DEPT MOLEC BIOL SIENA ITALY
Titolo Testata:
Nature genetics
fascicolo: 4, volume: 10, anno: 1995,
pagine: 466 - 471
SICI:
1061-4036(1995)10:4<466:DCLOTC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SEX-CHROMOSOMES; MOUSE X-CHROMOSOME; PSEUDOAUTOSOMAL REGION; CHLORIDE CHANNEL; INTERSPECIFIC HYBRIDS; ALPHA-SUBUNIT; HALDANE RULE; MALE MEIOSIS; DNA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
E.I. Rugarli et al., "DIFFERENT CHROMOSOMAL LOCALIZATION OF THE CLCN4 GENE IN MUS-SPRETUS AND C57BL 6J MICE/", Nature genetics, 10(4), 1995, pp. 466-471

Abstract

We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region, Our data provide molecular evidence for a major divergence near the pseudoautosomalregion, consistent with the hypothesis that hybrid sterility in thesespecies results from abnormal pairing of sex chromosomes during male meiosis.

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Documento generato il 06/07/20 alle ore 05:50:06