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Titolo:
IMPAIRMENT OF TESTICULAR ENDOCRINE FUNCTION AFTER LEAD-INTOXICATION IN THE ADULT-RAT
Autore:
THOREUXMANLAY A; DELACALLE JFV; OLIVIER MF; SOUFIR JC; MASSE R; PINONLATAILLADE G;
Indirizzi:
CEA,DIRECT SCI VIVANT,DEPT PATHOL & TOXICOL EXPTL,BOITE POSTALE 6 F-92265 FONTENAY ROSES FRANCE CEA,DIRECT SCI VIVANT,DEPT PATHOL & TOXICOL EXPTL F-92265 FONTENAY ROSES FRANCE UNIV RENNES 1,INSERM,U435,ETUD REPROD MALE GRP F-35042 RENNES FRANCE UNIV PARIS 11,HOP BICETRE F-94270 LE KREMLIN BICETR FRANCE
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 100, anno: 1995,
pagine: 101 - 109
SICI:
0300-483X(1995)100:1-3<101:IOTEFA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE-SYSTEM; GERM-CELLS; EXPOSURE; FERTILITY; TOXICITY; ACETATE; SERTOLI; SPERMATOZOA; EXPRESSION; MOVEMENT;
Keywords:
LEAD; RAT; TESTIS; TESTOSTERONE; LEYDIG CELLS; FERTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A. Thoreuxmanlay et al., "IMPAIRMENT OF TESTICULAR ENDOCRINE FUNCTION AFTER LEAD-INTOXICATION IN THE ADULT-RAT", Toxicology, 100(1-3), 1995, pp. 101-109

Abstract

To clarify the mechanism of the action of lead on male reproductive function, adult male rats were injected intraperitoneally (i.p.) with lead acetate (8 mg/kg/day of lead), 5 days a week for 35 days. Despite this high dose, germ cells and Sertoli cells did not appear to be major targets of lead. However, lead determination in the reproductive organs showed that the accessory sex glands are such a target, Epididymalfunction was unchanged. In lead-exposed rats, plasma and testicular testosterone dropped by about 80%, but plasma luteinizing hormone (LH) only dropped by 32%. After luteinizing hormone releasing hormone (LHRH) stimulation of the pituitary, the plasma LH level reached the control one, but plasma testosterone remained significantly reduced by 37%. The sharp decrease in the testosterone:LH ratio in lead-exposed rats, combined with the significant reduction of intertubular tissue volume in the testes, indicate impaired Leydig cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:56:20