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Titolo:
SYNCHRONOUS FLUCTUATION OF INTERLUEKIN-6 AND PLATELET COUNT IN CYCLICTHROMBOCYTOPENIA AND THROMBOCYTOSIS
Autore:
KUYAMA J; TAKE H; MATSUMOTO S; NAKAJIMA T; SUGASE T; HATA A; HANADA M; NAKAGAWA K;
Indirizzi:
TOYONAKA CITY HOSP,DEPT INTERNAL MED,2-1-1 OKAKAMINOCHO TOYONAKA OSAKA 560 JAPAN
Titolo Testata:
Internal medicine
fascicolo: 7, volume: 34, anno: 1995,
pagine: 636 - 639
SICI:
0918-2918(1995)34:7<636:SFOIAP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Keywords:
MENSTRUAL CYCLE; MEGAKARYOPOIESIS; GM-CSF; TGF-BETA; STIMULATORY CYTOKINE; INHIBITORY CYTOKINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J. Kuyama et al., "SYNCHRONOUS FLUCTUATION OF INTERLUEKIN-6 AND PLATELET COUNT IN CYCLICTHROMBOCYTOPENIA AND THROMBOCYTOSIS", Internal medicine, 34(7), 1995, pp. 636-639

Abstract

We describe a case of cyclic thrombocytopenia and thrombocytosis, whose cytokine levels, granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-6 (IL-6) in plasma, fluctuated in synchrony with platelet count, The levels of the two cytokines correlated significantly with the platelet count for 11 observations over an 8-month period (r=0.79, p<0.01 for GM-CSF and r=0.87, p<0.001 for IL-6), No inverse relationship between platelet-associated immunoglobulin G (PAIgG) and platelet count was observed (r=0.39, p>0.20). These findings suggestthat the fluctuation of platelet count in this case may result from an aberration of the cytokine network regulating megakaryopoiesis and platelet formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:01:18