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Titolo:
CORRELATION OF IN-VITRO AND IN-VIVO EFFECTS OF INTERFERON-GAMMA WITH THE SPONTANEOUS REGRESSION OF A RAT HISTIOCYTOMA
Autore:
KAUSALYA S; VARALAKSHMI C; KHAR A;
Indirizzi:
CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 7, volume: 15, anno: 1995,
pagine: 647 - 654
SICI:
1079-9907(1995)15:7<647:COIAIE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; SPONTANEOUS IMMUNOLOGICAL REGRESSION; STIMULATORY FACTOR; RECOMBINANT INTERLEUKIN-2; HUMAN-LYMPHOCYTES; T-CELLS; CYTOKINES; INDUCTION; INVIVO; LYMPHOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Kausalya et al., "CORRELATION OF IN-VITRO AND IN-VIVO EFFECTS OF INTERFERON-GAMMA WITH THE SPONTANEOUS REGRESSION OF A RAT HISTIOCYTOMA", Journal of interferon & cytokine research, 15(7), 1995, pp. 647-654

Abstract

Cytokines trigger activation of different lymphocyte populations, resulting in augmentation of humoral and cell-mediated immunity, We have examined the role of IFN-gamma in mediating AK-5 tumor regression, High levels of circulating IFN-gamma and IL-2 marked the process of regression, Moreover, interaction of immune NK cells with antibody-tagged AK-5 resulted in IFN-gamma secretion, providing in vitro evidence for the involvement of this cytokine, IFN-gamma and IL-2 potentiated the cytolytic activity of naive NK cells, suggesting their role in antitumoractivity, Furthermore, pretreatment of immune NK cells with protein tyrosine kinase inhibitor downregulated the IFN-gamma release, suggesting that the secretion of IFN-gamma is phosphorylation dependent, Nonimmune cells could be induced to secrete IFN-gamma when exposed to rIL-12, demonstrating IL-12 dependence in inducing IFN-gamma release, In vivo administration of anti-IFN-gamma inhibited the cytotoxic activity and the process of tumor regression, further substantiating the role ofIFN-gamma in regulating the rejection of AK-5 tumor, These observations suggest a definitive role for IFN-gamma in AK-5 regression, This cytokine in concert with IL-2 and IL-12 might aid in designing effectiveanticancer therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:41:29