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Titolo:
MICROBIAL INCITERS OF ACUTE ASTHMA IN URBAN NIGERIAN CHILDREN
Autore:
GBADERO DA; JOHNSON AWBR; ADERELE WI; OLALEYE OD;
Indirizzi:
UNIV ILORIN,DEPT CHILD HLTH,PMB 1515 ILORIN NIGERIA UCH,COLL MED,DEPT PAEDIAT,RESP & INFECT DIS UNIT IBADAN NIGERIA UCH,COLL MED,DEPT VIROL IBADAN NIGERIA
Titolo Testata:
Thorax
fascicolo: 7, volume: 50, anno: 1995,
pagine: 739 - 745
SICI:
0040-6376(1995)50:7<739:MIOAAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-SPECIFIC IGE; RESPIRATORY-INFECTIONS; WHEEZY BRONCHITIS; VIRAL-INFECTION; HYPERREACTIVITY; PRECIPITANTS; ASSOCIATION; RHINOVIRUS; PNEUMONIA; CHILDHOOD;
Keywords:
ACUTE ASTHMA; ACUTE RESPIRATORY INFECTIONS; VIRAL RESPIRATORY INFECTIONS; BACTERIAL ACUTE RESPIRATORY INFECTIONS; TROPICAL AFRICA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Gbadero et al., "MICROBIAL INCITERS OF ACUTE ASTHMA IN URBAN NIGERIAN CHILDREN", Thorax, 50(7), 1995, pp. 739-745

Abstract

Background - In tropical Africa the role of microbial agents of acuterespiratory infections in acute exacerbations of bronchial asthma remains largely unexplored. However, empirical antibacterial therapy is frequently initiated in moderate to severe cases of acute asthma with symptoms of acute respiratory infection. A study was set up to determine how often acute respiratory infection is associated with acute asthma, to identify the associated pathogens, and to proffer appropriate therapeutic suggestions. Methods - Over a 16 month period, 86 episodes of acute asthma were studied for clinical and laboratory features of acute respiratory infection at the University College Hospital (UGH), Ibadan. Virological diagnosis was based on immunofluorescence studies ofnasopharyngeal aspirates and/or serological tests using the microtitre complement fixation technique. Throat swabs and blood were cultured for bacterial agents. Results - Of the 64 cases who presented with rhinorrhoea, 51 (79.7%) were pyrexial (T equal to or greater than 37.6 degrees C). Inflammatory changes (frequently interstitial streakiness) were identified in 10 (19.6%) of the 51 chest radiographs; only two of these had lobar shadowing. Significant bacterial isolates were made inonly three (3.5%) of the throat swabs and two (2.4%) of the blood cultures from the 86 cases; none had clinical septicaemia. On the other hand, 55 viral agents were identified from 39 (53%) of the 74 subjects studied; 16 (41. 0%) had dual viral identifications. Respiratory syncytial virus (RSV) accounted for 20 (36.4%) identifications , parainfluenza virus (PIV) type 3 for 15 (27.3%), and influenza type A (Flu A) for 12 (21 8%). Viral identifications were significantly higher in infants and preschool subjects (<5 years) and in those presenting with either rhinorrhoea or pyrexia. Conclusions - The results of this study underscore the importance of viral upper respiratory infections in asthmaexacerbations in a tropical setting. The paucity of clinical and investigative features of bacterial acute respiratory infection suggests that there is little rationale for routine antibiotic cover in childrenwith acute exacerbations of asthma in the tropics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:54:30