Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYTOPROTECTIVE EFFECTS OF COLLOIDAL BISMUTH SUBCITRATE IN PATIENTS WITH ULCER DISEASE
Autore:
DOTTO P; FERRANA M; BO ND; SALANDIN S; KUSSTATSCHER S; CASSARO M; PLEBANI M; BATTAGLIA G; VIANELLO F; RUGGE M; DIMARIO F;
Indirizzi:
CATTEDRA MALATTIE APPARATO DIGERENTE,MONOBLOCCO,VIA GIUSTINIANI 2 I-35128 PADUA ITALY UNIV PADUA,DEPT GASTROENTEROL I-35100 PADUA ITALY UNIV PADUA,DEPT PATHOL I-35100 PADUA ITALY UNIV PADUA,DEPT CLIN CHEM I-35100 PADUA ITALY VENICE GEN HOSP,DEPT GASTROENTEROL VENICE ITALY
Titolo Testata:
Current therapeutic research
fascicolo: 7, volume: 56, anno: 1995,
pagine: 684 - 689
SICI:
0011-393X(1995)56:7<684:CEOCBS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIPOTASSIUM DICITRATO BISMUTHATE; PEPTIC-ULCER; DE-NOL; PEPSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P. Dotto et al., "CYTOPROTECTIVE EFFECTS OF COLLOIDAL BISMUTH SUBCITRATE IN PATIENTS WITH ULCER DISEASE", Current therapeutic research, 56(7), 1995, pp. 684-689

Abstract

Helicobacter pylori is capable of altering the structure of the mucusgel adhering to the surface of the gastric antral wall, Thirty patients (22 men and 8 women) with endoscopic evidence of active duodenal ulcer and histologically confirmed H pylori antral gastritis participated in this prospective study. The study objective was to evaluate the effects of 6 weeks of treatment with colloidal bismuth subcitrate (two 120-mg tablets twice daily) on peptic secretion and the gastric mucosal barrier. Samples of gastric juice were collected during endoscopy tomeasure pepsin levels, Also during endoscopy, four biopsies were taken (two antral and two from the body/fundus) for histologic examination, H pylori detection, and the quantification of pepsinogen group A (PGA), gastrin, and pepsin in the tissues, AH of the above parameters were repeated with endoscopy after 6 weeks of treatment. Ulcer healing was obtained in 26 (87%) of 30 patients after treatment. H pylori infection was cleared in 15 (50%) patients. No significant changes were detected in concentrations of pepsin in the gastric juice or concentrations of PGA, gastrin, or pepsin in the tissues. Mucus depletion was visibly lower after treatment, suggesting that colloidal bismuth subcitratemay alter the bacterial microenvironment, regenerating the quantity of mucus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:35:05