Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF TRYPTOPHAN DEPLETION ON RESPONSES TO YOHIMBINE IN HEALTHY-HUMAN SUBJECTS
Autore:
GODDARD AW; CHARNEY DS; GERMINE M; WOODS SW; HENINGER GR; KRYSTAL JH; GOODMAN WK; PRICE LH;
Indirizzi:
CONNECTICUT MENTAL HLTH CTR,ABRAHAM RIBICOFF RES FACIL,CLIN NEUROSCI RES UNIT,34 PK ST W HAVEN CT 06519 CONNECTICUT MENTAL HLTH CTR,ABRAHAM RIBICOFF RES FACIL,CLIN NEUROSCI RES UNIT NEW HAVEN CT 06519 YALE UNIV,DEPT PSYCHIAT NEW HAVEN CT 06520 VET ADM MED CTR W HAVEN CT 06516
Titolo Testata:
Biological psychiatry
fascicolo: 2, volume: 38, anno: 1995,
pagine: 74 - 85
SICI:
0006-3223(1995)38:2<74:EOTDOR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN RECEPTOR HYPERSENSITIVITY; LOCUS-COERULEUS NEURONS; PANIC DISORDER; NORADRENERGIC FUNCTION; PHARMACOLOGICAL CHARACTERIZATION; ELECTROPHYSIOLOGICAL EVIDENCE; RAT HIPPOCAMPUS; 5-HT2 RECEPTORS; DORSAL RAPHE; ANXIETY;
Keywords:
ANXIETY; SEROTONIN; NOREPINEPHRINE; MHPG; CORTISOL; TRYPTOPHAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Goddard et al., "EFFECTS OF TRYPTOPHAN DEPLETION ON RESPONSES TO YOHIMBINE IN HEALTHY-HUMAN SUBJECTS", Biological psychiatry, 38(2), 1995, pp. 74-85

Abstract

There is considerable evidence that both the norepinephrine (NE) and serotonin (5-HT) systems are involved in the regulation of human anxiety and fear responses. To assess the modulating effects of central 5-HT levels on NE function, II healthy human subjects were studied with placebo-controlled challenge tests involving tryptophan depletion followed by administration of the alpha-2-adrenergic antagonist yohimbine 0.4 mg/kg IV. Five of the 11 subjects reported a marked increase in feelings of nervousness (greater than or equal to 25 mm on a 100 mm analog scale) following the combination test, while 1/11 had this response to yohimbine alone. No subjects had an increase in nervousness during other control tests, The increase in nervousness after the tryptophan depletion-yohimbine test was statistically significant for the whole group, but there were no other unique changes in behavioral, physiologic or biochemical (MHPG, cortisol) variables with this rest, These dataare discussed in terms of possible functional interactions between the 5-HT and NE neurotransmitter systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:51:39