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Titolo:
UNUSUAL CASE OF CANDIDA-LUSITANIAE INFECTION IN A SEVERELY IMMUNOCOMPROMISED PATIENT - MULTIPLE LOCALIZATIONS OF A SINGLE INFECTIVE STRAIN DOCUMENTED BY RESTRICTION-ENDONUCLEASE ANALYSIS
Autore:
MICHELNGUYEN A; FAVEL A; PENAUD A; TROUSSON F; CARLOTTI A;
Indirizzi:
FAC PHARM MARSEILLE,LAB BOT CRYPTOGAMIE & BIOL CELLULAIRE,27 BLVD JEAN MOULIN F-13385 MARSEILLE 5 FRANCE CHU NORD,LAB BACTERIOL & PARASITOL F-13015 MARSEILLE FRANCE
Titolo Testata:
Journal de mycologie medicale
fascicolo: 4, volume: 6, anno: 1996,
pagine: 172 - 177
SICI:
1156-5233(1996)6:4<172:UCOCII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPPORTUNISTIC PATHOGEN; EPIDEMIOLOGY; DELINEATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Michelnguyen et al., "UNUSUAL CASE OF CANDIDA-LUSITANIAE INFECTION IN A SEVERELY IMMUNOCOMPROMISED PATIENT - MULTIPLE LOCALIZATIONS OF A SINGLE INFECTIVE STRAIN DOCUMENTED BY RESTRICTION-ENDONUCLEASE ANALYSIS", Journal de mycologie medicale, 6(4), 1996, pp. 172-177

Abstract

We describe a complex Candida lusitaniae infection in a splenectomized patient with homozygote drepanocytemia. The diagnosis was established on the basis of mycological and histopathologic evidence. Combination of amphotericin B and flucytosine eventually allowed the specimens to be sterilized and the treatment to succeed, thus confirming the diagnosis. Three infective strains of C, lusitaniae were recovered over the course of the infection from buccal lesions, a bronchoalveolar lavage and epidermic lesions at the edge of the lower lip. These isolates were susceptible in vitro to amphotericin B, flucytosine and fluconazole, with minimum inhibitory concentrations, as determined with the National Committee for Clinical Laboratory Standards reference macrodilution method, of 0.5, 0.03 and 1 mu g/ml, respectively. Restriction endonuclease analysis of total DNA was used to type the three isolates. In addition, four unrelated control strains were studied. By means of EcoRI and HinfI, restriction patterns of the infectious isolates were found to be identical (100 % similitude according to Jaccard's coefficient). In contrast, the four control strains generated four different patterns. These findings confirm the hypothesis that the Candida lusitaniae strain spread from a buccal lesion to the upper respiratory tract and to the face as suggested from the case analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:40:15