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Titolo:
PRESSURE-FLOW RELATIONSHIPS IN IN-VITRO MODEL OF COMPARTMENT SYNDROME
Autore:
SHRIER I; MAGDER S;
Indirizzi:
SIR MORTIMER B DAVIS JEWISH HOSP,HERZL FAMILY PRACTICE CTR,RM E-0010,5757 LEGARE MONTREAL PQ H3T 1Z6 CANADA SIR MORTIMER B DAVIS JEWISH HOSP,LADY DAVIS INST MONTREAL PQ H3T 1Z6 CANADA ROYAL VICTORIA HOSP,DIV CRIT CARE MONTREAL PQ H3A 1A1 CANADA MCGILL UNIV,MEAKINS CHRISTIE LABS MONTREAL PQ H3T 1Z6 CANADA
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 79, anno: 1995,
pagine: 214 - 221
SICI:
8750-7587(1995)79:1<214:PRIIMO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED SKELETAL-MUSCLE; MYOGENIC RESPONSE; CORONARY; CAPACITANCE; ARTERIOLES; HEART; DOG;
Keywords:
VASCULAR WATERFALL; CRITICAL CLOSING PRESSURE; ARTERIAL RESISTANCE; VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
I. Shrier e S. Magder, "PRESSURE-FLOW RELATIONSHIPS IN IN-VITRO MODEL OF COMPARTMENT SYNDROME", Journal of applied physiology, 79(1), 1995, pp. 214-221

Abstract

Compartment syndrome is a condition in which an increase in intramuscular pressure decreases blood flow to skeletal muscle. According to the Starling resistor (i.e., vascular waterfall) model of blood flow, the decrease in flow could occur through an increase in arterial resistance (Rart) or an increase in the critical closing pressure (Pcrit). Todetermine which explains the decrease in flow, we pump perfused a canine gastrocnemius muscle placed within an airtight box, controlled boxpressures (Pbox) so that flow ranged from 100 to 50%, and measured Pcrit, Rart, arterial compliance, small venular pressure (measured by the double-occlusion technique), and venous pressure. An increase in Pbox limited flow mainly through an increase in Pcrit (75-85%), with onlysmall changes in Rart (15-25%) and no change in arterial compliance. Increases in Pbox also produced a vascular waterfall in the venous circulation, but small venular transmural pressure always remained less than control levels. We conclude that increases in Pbox mostly limit blood flow through increases in Pcrit and that Rart plays a minor role. Transmural pressure across the small venules decreases with increases in intramuscular pressure, which contradicts the currently held beliefthat compartment syndrome is due to a cycle of swelling-ischemia swelling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:12:05