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Titolo:
INFLUENCE OF CARDIAC ACTION ON GAS MIXING IN CLOSED-CHEST DOGS
Autore:
ZHANG SP; SALTZMAN AR; KLOCKE RA;
Indirizzi:
SUNY BUFFALO,DEPT MED,462 GRIDER ST BUFFALO NY 14215 SUNY BUFFALO,DEPT MED BUFFALO NY 14215 SUNY BUFFALO,DEPT PHYSIOL BUFFALO NY 14215
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 79, anno: 1995,
pagine: 113 - 120
SICI:
8750-7587(1995)79:1<113:IOCAOG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-VOLUME; OSCILLATIONS; OXYGEN; MODEL;
Keywords:
CONVECTION; DIFFUSION; DEAD SPACE; SINGLE-BREATH TEST; SLOPE OF PHASE III; CARDIOGENIC OSCILLATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Zhang et al., "INFLUENCE OF CARDIAC ACTION ON GAS MIXING IN CLOSED-CHEST DOGS", Journal of applied physiology, 79(1), 1995, pp. 113-120

Abstract

We performed single-breath tests in closed-chest, paralyzed, and anesthetized dogs (6 with bilateral vagotomy and 6 with intact vagi) with the heart beating and during cardiac arrest. Repeated cardiac arrest was achieved by ventricular fibrillation and subsequent defibrillation. Twenty-four single-breath tests per dog were performed in combinations of three inspiratory volumes (VI; 0.2, 0.5, and 0.8 liter) and four postinspiratory pauses (0, 5, 10, and 30 s), either with or without cardiac arrest. The test gas contained four inert relatively insoluble gases (He, Ne, Ar, and SF6) with a sixfold range in diffusivity. Seriesdead space (VD) decreased with increasing postinspiratory pause, increasing gas diffusivity, or decreasing VI. In vagotomized animals, VD was smaller with the heart beating than during cardiac arrest, but thisrelationship was reversed in animals with intact vagi. The decrease in VD due to cardiogenic mixing accounted for only 10.8% of the total decrease in VD occurring during a 30-s postinspiratory pause. The slopeof phase III decreased with increasing postinspiratory pause except at VI of 0.2 liter. No significant differences were noted in the slope of phase III between experiments performed with the heart beating or arrested. Tracer gas retained in the residual volume after expiration increased with increasing inspiratory pause. Gas retention was greater for He than for SF6 but was not affected by cardiac action. These findings indicate that cardiac action mainly affects the interface betweeninspired and alveolar gas and has little effect on mixing in the alveolar compartment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:46:59