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Titolo:
PROTECTIVE EFFECTS OF YANGAMBIN - A NATURALLY-OCCURRING PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR ANTAGONIST ON ANAPHYLACTIC SHOCK IN RATS
Autore:
RIBEIRO R; CARVALHO FAS; BARBOSA JM; CORDEIRO RSB; TIBIRICA EV;
Indirizzi:
FIOCRUZ MS,INST OSWALDO CRUZ,DEPT FISIOL & FARMACODINAM,AV BRASIL 4365 MANGUINHOS BR-21045900 RIO JANEIRO BRAZIL UNIV FED PARAIBA,LAB TECNOL FARMACEUT BR-58059900 JOAO PESSOA PARAIBABRAZIL
Titolo Testata:
Phytomedicine
fascicolo: 3, volume: 3, anno: 1996,
pagine: 249 - 256
SICI:
0944-7113(1996)3:3<249:PEOY-A>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; ENDOTOXIN; ACETHER; HYPOTENSION; HISTAMINE; WEB-2086; CORONARY; TCV-309; RABBIT; DOGS;
Keywords:
(+)-YANGAMBIN, OCOTEA DUCKEI VATTIMO (LAURACEAE), PAF RECEPTOR ANTAGONIST; SYSTEMIC ANAPHYLAXIS, ARTERIAL HYPOTENSION, SHOCK, ANAPHYLACTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
R. Ribeiro et al., "PROTECTIVE EFFECTS OF YANGAMBIN - A NATURALLY-OCCURRING PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR ANTAGONIST ON ANAPHYLACTIC SHOCK IN RATS", Phytomedicine, 3(3), 1996, pp. 249-256

Abstract

The purpose of this study was to investigate the ability of yangambinto inhibit cardiovascular collapse and to reduce the mortality due tosystemic anaphylaxis induced by antigen challenge in actively sensitized rats. The i.v. injection of the antigen (ovalbumin, 250 or 500 mu g/kg), induced a systemic anaphylactic reaction mainly characterized by sudden and marked arterial hypotension and high mortality rates. Yangambin, a PAF receptor antagonist isolated from the Brazilian plant Ocotea duckei Vattimo (Lauraceae), as well as the reference PAF receptorantagonist SR 27417, significantly prevented and partially reversed the circulatory collapse elicited by antigen challenge. Moreover, yangambin and SR 27417, when administered 5 min before re-exposure of the animals to the antigen, markedly improved the survival rate at 120 min. These results confirm that PAF plays an important role in the pathophysiology of anaphylactic shock and show that yangambin presents good therapeutic potential in the treatment of the cardiovascular alterations observed during immediate hypersensitivity reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 14:50:14