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Titolo:
THE RATIO BETWEEN ANIONIC AND CATIONIC TRYPSIN IN RAT PANCREAS VARIESWITH CCK STIMULATION
Autore:
BORGSTROM A; AXELSON J; IHSE I; REHFELD JF;
Indirizzi:
LUND UNIV,MALMO GEN HOSP,DEPT SURG S-21401 MALMO SWEDEN LUND UNIV,MALMO GEN HOSP,DEPT SURG PATHOPHYSIOL S-21401 MALMO SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN RIGSHOSP,DEPT CLIN BIOCHEM DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Pancreas
fascicolo: 2, volume: 11, anno: 1995,
pagine: 179 - 184
SICI:
0885-3177(1995)11:2<179:TRBAAC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATICOBILIARY DIVERSION; NUCLEOTIDE-SEQUENCES; CHOLECYSTOKININ; SERUM; AMYLASE; GROWTH; CDNAS;
Keywords:
ANIONIC TRYPSIN; CATIONIC TRYPSIN; AMYLASE; CHOLECYSTOKININ; DEVAZEPIDE; PANCREAS; PANCREATICOBILIARY DIVERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Borgstrom et al., "THE RATIO BETWEEN ANIONIC AND CATIONIC TRYPSIN IN RAT PANCREAS VARIESWITH CCK STIMULATION", Pancreas, 11(2), 1995, pp. 179-184

Abstract

The effects of long-term hyperstimulation with cholecystokinin (CCK) on the pancreatic contents of anionic and cationic trypsin(ogen) and amylase were studied in the rat. Endogenous hyperCCKemia was evoked in rats by pancreaticobiliary diversion (PBD), and exogenous hyperCCKemiaby continuous subcutaneous CCK infusion, In addition, the effect of continuous subcutaneous infusion of the CCK A receptor antagonist devazepide was studied. After 4 weeks blood samples were obtained for the determination of plasma CCK concentrations and the animals were sacrificed. The pancreatic glands were harvested, weighed, and extracted. Theextracts were analyzed for anionic and cationic trypsin and amylase. Enzyme contents showed a large interindividual variation. The most consistent change in enzyme pattern was an increase in the ratio between anionic and cationic trypsin in animals with hyperCCKemia (PBD operated or CCK infused). Furthermore, this ratio decreased significantly in animals treated with devazepide. In conclusion, stimulation of the CCKreceptor changed the ratio between anionic and cationic trypsin in the pancreatic gland, while it was reversed during blockade of the receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:03:48