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Titolo:
A BRANCH IN THE TOXR REGULATORY CASCADE OF VIBRIO-CHOLERAE REVEALED BY CHARACTERIZATION OF TOXT MUTANT STRAINS
Autore:
CHAMPION GA; NEELY MN; BRENNAN MA; DIRITA VJ;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT MICROBIOL & IMMUNOL ANN ARBOR MI 48108 UNIV MICHIGAN,SCH MED,DEPT MICROBIOL & IMMUNOL ANN ARBOR MI 48108 UNIV MICHIGAN,SCH MED,CELLULAR BIOTECHNOL PROGRAM ANN ARBOR MI 48108 UNIV MICHIGAN,SCH MED,UNIT LAB ANIM MED ANN ARBOR MI 48108
Titolo Testata:
Molecular microbiology
fascicolo: 2, volume: 23, anno: 1997,
pagine: 323 - 331
SICI:
0950-382X(1997)23:2<323:ABITTR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL ACTIVATORS; ESCHERICHIA-COLI; SIGNAL-TRANSDUCTION; MEMBRANE-PROTEIN; SUICIDE VECTOR; ARAC FAMILY; VIRULENCE; GENES; IDENTIFICATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Champion et al., "A BRANCH IN THE TOXR REGULATORY CASCADE OF VIBRIO-CHOLERAE REVEALED BY CHARACTERIZATION OF TOXT MUTANT STRAINS", Molecular microbiology, 23(2), 1997, pp. 323-331

Abstract

Co-ordinate expression of genes associated with pathogenicity in Vibrio cholerae requires two transcription activators, ToxR and ToxT. Workcarried out to date suggests that ToxR activates transcription of thetoxT gene and that ToxT directly activates transcription of several genes whose products play a role in colonization or CT production by V.cholerae. Previous work also suggests that ToxR can directly activatetranscription of the CT operon (ctxAB) independently of ToxT, therebyimplying a degree of complexity in control of the ctxAB operon not found with other genes of the ToxR regulon. We tested the regulatory cascade model of virulence gene expression by constructing strains of classical and El Tor V. cholerae deleted for the coding sequence for the putative DNA-binding domain of toxT. Phenotypic analysis of these strains suggests that V. cholerae has ToxT-dependent and ToxT-independent branches of its virulence regulon. The results also raise questions about the precise role for ToxR in activation of ctxAB transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 02:14:43