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Titolo:
ADENOSINE MODULATES HYPOXIA-INDUCED ATRIAL-NATRIURETIC-PEPTIDE RELEASE IN FETAL SHEEP
Autore:
OGUNYEMI DA; KOOS BJ; ARORA CP; CASTRO LC; MASON BA;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT OBSTET & GYNECOL,NICHOLAS S ASSALI PERINATAL RES LAB LOS ANGELES CA 90024 CEDARS SINAI MED CTR,CEDARS SINAI RES INST,DEPT OBSTET & GYNECOL LOS ANGELES CA 90048
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 38, anno: 1995,
pagine: 282 - 287
SICI:
0363-6135(1995)38:1<282:AMHAR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-RESPONSES; BLOOD-VOLUME; ISOLATED RAT; HUMAN PLACENTA; ANF RELEASE; SLEEP STATE; PLASMA; HYPOXEMIA; SECRETION; TISSUES;
Keywords:
BLOOD PRESSURE; BLOOD VOLUME; CARDIOVASCULAR; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Ogunyemi et al., "ADENOSINE MODULATES HYPOXIA-INDUCED ATRIAL-NATRIURETIC-PEPTIDE RELEASE IN FETAL SHEEP", American journal of physiology. Heart and circulatory physiology, 38(1), 1995, pp. 282-287

Abstract

The effects of adenosine on atrial natriuretic peptide (ANP) secretion were determined in chronically catheterized fetal sheep (> 0.8 term). Adenosine was infused into the the right jugular vein for 1 h at 8 +/- 0.4 (5 fetuses), 160 +/- 8 (6 fetuses), and 344 +/- 18 mu g . min(-1). kg estimated fetal wt(-1). Fetal arterial blood gases and pH were generally unaffected by adenosine, although mean arterial CO2 tension increased transiently by 2-5 Torr and pH fell progressively during thehighest rate of infusion. During the intermediate and high infusion rates, fetal hemoglobin concentrations increased by 11-13% and mean fetal heart rate rose by 18% from a control value of similar to 167 beats/min. Mean arterial pressure was not affected during adenosine infusion. Adenosine significantly increased fetal plasma ANP levels, with maximum concentrations 1.80, 2.36, and 2.51 times greater than control means (142-166 pg/ml) for the respective infusion rates of 8, 160, and 344 mu g . min(-1). kg estimated fetal wt(-1). In seven fetuses, reducing fetal arterial O-2 tension by similar to 9-10 Torr from a control of 23 +/- 1.3 Torr increased plasma ANP concentrations similar to 2.4 times the control mean of 176 pg/min. Adenosine-receptor blockade with 8-(p-sulfophenyl)-theophylline reduced by 50% the maximum hypoxia-induced rise in plasma ANP concentrations. It is concluded that adenosine causes a dose-dependent rise in fetal plasma ANP concentrations and modulates fetal ANP release during hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:41:09