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Titolo:
HEMODYNAMIC BASIS OF OSCILLATIONS IN SYSTEMIC ARTERIAL-PRESSURE IN CONSCIOUS RATS
Autore:
JANSSEN BJA; OOSTING J; SLAAF DW; PERSSON PB; STRUIJKERBOUDIER HAJ;
Indirizzi:
UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,DEPT PHARMACOL,POB 616 6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,DEPT BIOPHYS 6200 MD MAASTRICHT NETHERLANDS HUMBOLDT UNIV BERLIN,DEPT PHYSIOL D-10115 BERLIN GERMANY
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 38, anno: 1995,
pagine: 62 - 71
SICI:
0363-6135(1995)38:1<62:HBOOIS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BLOOD-FLOW; SPONTANEOUSLY HYPERTENSIVE RATS; SPECTRAL-ANALYSIS; TUBULOGLOMERULAR FEEDBACK; HEART-RATE; R-R; AUTOREGULATION; DOGS; VARIABILITY; HUMANS;
Keywords:
AUTOREGULATION; BAROREFLEX; CENTRAL HEMODYNAMICS; MAYER WAVES; MYOGENIC RESPONSE; REGIONAL HEMODYNAMICS; TRANSFER FUNCTION ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
B.J.A. Janssen et al., "HEMODYNAMIC BASIS OF OSCILLATIONS IN SYSTEMIC ARTERIAL-PRESSURE IN CONSCIOUS RATS", American journal of physiology. Heart and circulatory physiology, 38(1), 1995, pp. 62-71

Abstract

In conscious resting rats, beat-to-beat fluctuations in systemic meanarterial pressure (MAP) were compared with those in cardiac output and those in blood flow in the renal, mesenteric, and hindquarter vascular beds. Spontaneous oscillations (lability) in MAP were observed in frequency bands centered about 1.6 Hz (high: HF), 0.4 Hz (mid: MF), and0.13 Hz (low: LF). Lability of MAP was confined within the LF (approximate to 8 s) band. Lability of cardiac output, on the other hand, showed primary HF oscillations. LF oscillations in regional blood how were most prominent in the mesenteric and renal vascular beds. In these beds, LF oscillations in blood flow showed negative phase angles with MAP, whereas those between MAP and hindquarter blood flow were positive. Cross correlation analysis indicated that similar to 2 s following aLF change in MAP, LF changes in mesenteric and renal blood flow occurred opposite to those of MAP. Changes in hindquarter flow were negatively correlated with those in MAP about zero time delay. Admittance gains were greater than or equal to 1 across all frequencies for all vascular beds, indicating the absence of autoregulation. This hemodynamic pattern suggests that myogenic mechanisms predominantly control mesenteric and renal blood flow in a nonautoregulatory but rather superregulatory manner, while autonomic mechanisms regulate hindquarter blood flow. Thus, in conscious resting rats, spontaneous fluctuations in systemic arterial pressure predominantly exhibit slow (approximate to 8 s) oscillations, which do not arise from fluctuations in cardiac output, but originate from regionally specific myogenic oscillatory mechanismscontributing to resistance to flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:14:25