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Titolo:
DOWN-REGULATION BY CRYPTOCOCCAL POLYSACCHARIDE OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA SECRETION FROM HUMAN MONOCYTES
Autore:
VECCHIARELLI A; RETINI C; PIETRELLA D; MONARI C; TASCINI C; BECCARI T; KOZEL TR;
Indirizzi:
UNIV PERUGIA,DEPT EXPTL MED & BIOCHEM SCI,MICROBIOL SECT,VIA DELGIOCHETTO I-06122 PERUGIA ITALY UNIV PERUGIA,DEPT CELLULAR & MOLEC BIOL,BIOCHEM & MOLEC BIOL SECT I-06122 PERUGIA ITALY UNIV NEVADA,SCH MED,DEPT MICROBIOL RENO NV 89557
Titolo Testata:
Infection and immunity
fascicolo: 8, volume: 63, anno: 1995,
pagine: 2919 - 2923
SICI:
0019-9567(1995)63:8<2919:DBCPOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-CANDIDA ACTIVITY; NATURAL-KILLER-CELLS; CAPSULAR POLYSACCHARIDE; HUMAN-LYMPHOCYTES; T-CELLS; NEOFORMANS; PHAGOCYTOSIS; MACROPHAGES; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A. Vecchiarelli et al., "DOWN-REGULATION BY CRYPTOCOCCAL POLYSACCHARIDE OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA SECRETION FROM HUMAN MONOCYTES", Infection and immunity, 63(8), 1995, pp. 2919-2923

Abstract

The regulation by Cryptococcus neoformans encapsulation of interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) production by human monocytes was investigated. By using encapsulated and acapsular C. neoformans, we demonstrated that both strains induce cytokine production, although the acapsular strain was a better stimulator than the thinly encapsulated strain. The cytokine levels produced by cells stimulated by the two strains were lower and followed a differentkinetic than those stimulated by lipopolysaccharide (LPS). Purified capsular polysaccharide inhibits TNF-alpha secretion induced by LPS or acapsular C. neoformans. In contrast, no regulatory effect on IL-1 beta was observed when LPS was used. The secretory response of these cytokines follows different pathways of macrophage activation; in fact, complete inhibition of TNF-alpha does not affect IL-1 beta-production and vice versa. These data indicate that purified capsular polysaccharide of C. neoformans could contribute to the in vivo progress of cryptococcosis by suppressing cytokine production of macrophages and suggest that a therapeutic approach to address the suppressive effect of cryptococcal polysaccharide could be devised.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:20:29