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Titolo:
ALZHEIMER AMYLOID BETA-PEPTIDES EXHIBIT IONOPHORE-LIKE PROPERTIES IN HUMAN ERYTHROCYTES
Autore:
ENGSTROM I; RONQUIST G; PETTERSSON L; WALDENSTROM A;
Indirizzi:
UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN MALAR HOSP,DEPT CLIN CHEM ESKILSTUNA SWEDEN
Titolo Testata:
European journal of clinical investigation
fascicolo: 7, volume: 25, anno: 1995,
pagine: 471 - 476
SICI:
0014-2972(1995)25:7<471:AABEIP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESSENTIAL-HYPERTENSION; CORTICAL-NEURONS; PROTEIN; DISEASE; CALCIUM; ACTIVATION; MEMBRANES; PRECURSOR; FRAGMENT; CELLS;
Keywords:
ALZHEIMER; AMYLOID; CALCIUM IONS; ERYTHROCYTES; IONOPHORE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
I. Engstrom et al., "ALZHEIMER AMYLOID BETA-PEPTIDES EXHIBIT IONOPHORE-LIKE PROPERTIES IN HUMAN ERYTHROCYTES", European journal of clinical investigation, 25(7), 1995, pp. 471-476

Abstract

There is growing evidence that the amyloid beta-peptide (beta(1-40)) is involved in the aetiology of Alzheimer's disease also implicating an altered calcium homeostasis of affected cells. Beta(1-40) has been proposed to form calcium channels in synthetic bilayer membranes [1]. We wanted to investigate in the present study whether beta(1-40) (or fragments thereof) could act as ionophores in a biological membrane likethe one in human erythrocytes. Incubation of the cells for 2 h and 4 h at 37 degrees C together with 6 mu mol L(-1) of beta(1-40) or of fragments beta(1-28) and beta(25-35), resulted in a significantly decreased energy charge qualitatively similar to the one obtained by a known calcium ionophore (A 23187, 0.05 mu mol L(-1)). Moreover, beta(1-40) and its two fragments induced a significant alteration of Ca-45 permeability in human red blood cells of the same type as the one achieved bythe calcium ionophore. The ionophoric action of beta(1-40) and its two fragments may lead to an increase of the intracellular calcium ion concentration, in turn resulting in enhanced Ca2+-ATPase activity and adecrease in energy charge. This may be valid also for neuronal plasmamembranes and could, therefore, be a possible aetiological mechanism in Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:10:50