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Titolo:
THE INSULIN ACTION-FIBER TYPE RELATIONSHIP IN HUMANS IS MUSCLE GROUP-SPECIFIC
Autore:
HICKEY MS; WEIDNER MD; GAVIGAN KE; ZHENG DH; TYNDALL GL; HOUMARD JA;
Indirizzi:
E CAROLINA UNIV,HUMAN PERFORMANCE LAB,371 SPORTS MED BLDG GREENVILLE NC 27858
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 1, volume: 32, anno: 1995,
pagine: 150 - 154
SICI:
0193-1849(1995)32:1<150:TIATRI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; RESISTANT PATIENTS; GLUCOSE-UPTAKE; OBESITY; INVIVO; RATS; EXPRESSION; GLUT-4;
Keywords:
INSULIN RESISTANCE; SKELETAL MUSCLE; ABDOMINAL OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Hickey et al., "THE INSULIN ACTION-FIBER TYPE RELATIONSHIP IN HUMANS IS MUSCLE GROUP-SPECIFIC", American journal of physiology: endocrinology and metabolism, 32(1), 1995, pp. 150-154

Abstract

The purpose of the present investigation was to determine the relationship between skeletal muscle characteristics, adiposity, and in vivo insulin action. Percutaneous muscle biopsies of the vastus lateralis (VL) and gastrocnemius (G) muscles were obtained from twenty-two sedentary male subjects. Insulin sensitivity (S-I) and glucose effectiveness(S-G) were determined from minimal model analysis, and indexes of regional and overall adiposity were obtained. S-I was positively related to the citrate synthase activity from the VL (r = 0.50, P < 0.01) but unrelated to the citrate synthase activity from the G (r = 0.28). Similarly, S-I was inversely related to the percentage of type IIb fibers in the VL (r = -0.47, P < 0.01) but unrelated to the percentage of type Im fibers in the G (r = 0.06). S-G was unrelated to fiber type, oxidative capacity, or adiposity. These data suggest that oxidative capacity and other characteristics related to VL skeletal muscle fiber type are determinants of in vivo insulin action but that this relationship cannot be extended to all muscle groups. Finally, neither skeletal muscle characteristics nor adiposity appears to be a determinant of S-G in sedentary males.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:23:28