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Titolo:
REGULATION OF CHOLESTERYL ESTER TRANSFER ACTIVITY IN ADIPOSE-TISSUE -COMPARISON BETWEEN HAMSTER AND RAT-SPECIES
Autore:
SHEN GX; ANGEL A;
Indirizzi:
UNIV MANITOBA,DEPT INTERNAL MED,730 WILLIAM AVE,BS439 WINNIPEG MB R3E3J7 CANADA UNIV MANITOBA,DEPT PHYSIOL WINNIPEG MB R3E 3J7 CANADA
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 1, volume: 32, anno: 1995,
pagine: 99 - 107
SICI:
0193-1849(1995)32:1<99:ROCETA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; TRANSFER PROTEIN; PLASMA-LIPOPROTEINS; PROBUCOL TREATMENT; TRANSGENIC MICE; MESSENGER-RNA; TRIGLYCERIDE; ADIPOCYTES; RECEPTOR; BINDING;
Keywords:
RAT AND HAMSTER ADIPOSE TISSUE; INSULIN; FASTING; HIGH-CHOLESTEROL SATURATED FAT-RICH DIET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G.X. Shen e A. Angel, "REGULATION OF CHOLESTERYL ESTER TRANSFER ACTIVITY IN ADIPOSE-TISSUE -COMPARISON BETWEEN HAMSTER AND RAT-SPECIES", American journal of physiology: endocrinology and metabolism, 32(1), 1995, pp. 99-107

Abstract

The present study demonstrates cholesteryl ester transfer activity (CETA) in cultured hamster and rat adipose tissue. Cultured hamster and rat adipose tissue fragments released CETA into the conditioned medium, and this was associated with a reciprocal decrease in adipose tissueCETA. Regional variations in adipose CETA were observed. The levels of CETA released from cultured hamster and rat adipocytes were higher than those from adipose tissue fragments. In hamsters but not in rats, the secretion of CETA from cultured adipose tissue was increased by insulin and inhibited by EDTA in a dose-dependent fashion. Monoclonal antibodies against human cholesteryl ester transfer protein inhibited the CETA secreted from hamster adipose tissue but not that from rat adipose tissue. Fasting for 24 h and a high-cholesterol saturated fat-richdiet increased adipose CETA in hamsters and rats, and this was associated with an elevation of plasma CETA only in hamsters. This supports the view that, in hamsters, adipose CETA has in situ and intravascularfunctions, whereas in rats the role of adipose CETA is restricted to tissue-specific functions. Hamster cholesteryl ester transfer protein may differ from rat adipose-associated CETA in the structure of the active site and the regulatory mechanism for its secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:38:38