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Titolo:
HYPOTHALAMIC SITES MEDIATING CARDIOVASCULAR EFFECTS OF MICROINJECTED BICUCULLINE AND EAAS IN RATS
Autore:
DENOVELLIS V; STOTZPOTTER EH; MORIN SM; ROSSI F; DIMICCO JA;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL INDIANAPOLIS IN 46202 UNIV NAPLES,FAC MED & SURG 1,INST PHARMACOL & TOXICOL I-80138 NAPLES ITALY
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 38, anno: 1995,
pagine: 131 - 140
SICI:
0363-6119(1995)38:1<131:HSMCEO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED TACHYCARDIA; AMINO-ACID RECEPTORS; PLUS-MAZE TEST; PARAVENTRICULAR NUCLEUS; DORSOMEDIAL HYPOTHALAMUS; POSTERIOR HYPOTHALAMUS; SYMPATHETIC OUTFLOW; REGULATE ANXIETY; GABA ANTAGONISTS; DEFENSE REACTION;
Keywords:
DORSOMEDIAL HYPOTHALAMIC NUCLEUS; PARAVENTRICULAR NUCLEUS; GAMMA-AMINOBUTYRIC ACID; EXCITATORY AMINO ACIDS; GLUTAMATE RECEPTORS; SYMPATHETIC NERVOUS SYSTEM; HEART RATE; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
V. Denovellis et al., "HYPOTHALAMIC SITES MEDIATING CARDIOVASCULAR EFFECTS OF MICROINJECTED BICUCULLINE AND EAAS IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 38(1), 1995, pp. 131-140

Abstract

Microinjection of the gamma-aminobutyric acid(A), receptor antagonistbicuculline methiodide (BMI) into either the dorsomedial hypothalamicnucleus (DMH) or the nearby paraventricular hypothalamic nucleus (PVN) has been reported to evoke marked tachycardia and modest presser effects. We compared the effects of microinjecting BMI and excitatory amino acids (EAAs) into 1) the DMH, 2) the PVN, and 3) an intermediate area between the two nuclei. In conscious rats, microinjection of (in pmol) 10 BMI, 0.5 kainic acid, or 5 N-methyl-D-aspartate into the DMH markedly increased heart rate and slightly elevated arterial pressure, whereas injections into other regions provoked changes that progressively declined in magnitude with increasing distance from the nucleus. A similar pattern was evident in urethan-anesthetized rats, where the shortest latency to onset of BMI-induced increases in heart rate was seen after injection into the DMH. These findings demonstrate that the cardiovascular changes seen after microinjection of BMI or EAAs into themedial hypothalamus result from an action in the DMH and not from spread to the PVN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:02:47