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Titolo:
A NOVEL RING-H2 MOTIF PROTEIN DOWN-REGULATED BY AXOTOMY - ITS CHARACTERISTIC LOCALIZATION AT THE POSTSYNAPTIC DENSITY OF AXOSOMATIC SYNAPSE
Autore:
NAKAYAMA M; MIYAKE T; GAHARA Y; OHARA O; KITAMURA T;
Indirizzi:
SHIONOGI & CO LTD,SHIONOGI RES LABS,FUKUSHIMA KU,5-12-4 SAGISU OSAKA 553 JAPAN SHIONOGI & CO LTD,SHIONOGI RES LABS,FUKUSHIMA KU OSAKA 553 JAPAN
Titolo Testata:
The Journal of neuroscience
fascicolo: 7, volume: 15, anno: 1995,
parte:, 2
pagine: 5238 - 5248
SICI:
0270-6474(1995)15:7<5238:ANRMPD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; FACIAL-NERVE AXOTOMY; MESSENGER-RNA; ZINC-FINGER; INSITU HYBRIDIZATION; GENE-EXPRESSION; RAT-BRAIN; SEQUENCE; IDENTIFICATION; ELECTROPHORESIS;
Keywords:
NEURODAP 1; AXOTOMY; FACIAL NERVE; SUBTRACTIVE DIFFERENTIAL SCREENING; THE RING-H2 MOTIF; POSTSYNAPTIC DENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakayama et al., "A NOVEL RING-H2 MOTIF PROTEIN DOWN-REGULATED BY AXOTOMY - ITS CHARACTERISTIC LOCALIZATION AT THE POSTSYNAPTIC DENSITY OF AXOSOMATIC SYNAPSE", The Journal of neuroscience, 15(7), 1995, pp. 5238-5248

Abstract

Axonal injury and its repair are common and basic neuropathological processes in the CNS, and are composed of a complex of events in a molecular term, In order to get a comprehensive understanding of these processes, we isolated several known and unknown genes which were up- or downregulated in the facial nucleus after transection of the facial nerve by a subtractive/differential screening. Among them, we focus on one downregulated gene, named Neurodap1, because this gene encodes a novel protein carrying the RING-H2 sequence motif categorized in the zinc finger family, Immunoelectron microscopic analysis revealed that theprotein encoded by Neurodap1, Neurodap1, was distributed mainly on the cytoplasmic side of the membranes constituting endoplasmic reticulumand Golgi apparatus, supporting the notion of a previously postulatedfunction of RING-HP motif proteins, that is, involvement in the protein sorting machinery, More interestingly, Neurodap1 was also bound to the postsynaptic density (PSD) region of axosomatic synapses, This fact suggests that Neurodap1 is associated with a specific system sortingproteins to PSD, Therefore, Neurodap1, a newly identified protein as an axotomy-suppressed gene product, might play a significant role in synaptic communication and plasticity through the control of the formation of PSD for maintaining vital functions of nerve cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:04:05