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Titolo:
CARCINOGENESIS - ENVIRONMENT AND GENETICS
Autore:
VONMUHLENDAHL KE; OTTO M;
Indirizzi:
AKAD KINDERHEILKUNDE & JUGENDMED,KINDERHOSP OSNABRUCK D-49082 OSNABRUCK GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 6, volume: 143, anno: 1995,
pagine: 567 - 571
SICI:
0026-9298(1995)143:6<567:C-EAG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Keywords:
CARCINOGENESIS; CANCEROGENESIS; TUMOR INITIATION; CARCINOGENS; ONCOGENES; ONCOPROTEINS; TUMOR SUPPRESSOR GENES; TUMOR SUPPRESSOR PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Vonmuhlendahl e M. Otto, "CARCINOGENESIS - ENVIRONMENT AND GENETICS", Monatsschrift fur Kinderheilkunde, 143(6), 1995, pp. 567-571

Abstract

In carcinogenesis, both individual disposition and external factors are important. Age, sex, hormones, and psyche play a role. But oncogenesis probably is mainly a result of genetic damage, of the accumulationof activated proto-oncogenes and the inactivation of tumor suppressorFor instance, ras-oncogenes and inactivation of the p53-gene are found in many malignant tumors and in precancerous lesions. Vulnerability of genetic material responsible for tumorigenesis is inherited. Changes may occur spontaneously, or genotoxic substances or conditions as ionising radiation and UV light induce, for instance, point mutations, translocations or gene amplification. This can take place long before the manifestation of a tumor. Generally, activation not only of one, but of several proto-oncogenes and inactivation of suppressor genes coincide in the development of many tumors. A rather complete picture of tumorigenesis starts to emerge. However, many white regions await further description. Prevention and therapy will profit from these new insights into tumor initiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:46:04