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Titolo:
DAYTIME WAKING AUTONOMIC FUNCTION AND VASCULAR CONTROL IN OSA
Autore:
HEDNER J;
Indirizzi:
SAHLGRENS UNIV HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Journal of sleep research
, volume: 4, anno: 1995, supplemento:, 1
pagine: 171 - 175
SICI:
0962-1105(1995)4:<171:DWAFAV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP-APNEA; EPISODIC HYPOXIA; BLOOD-PRESSURE; L-ARGININE; HYPERTENSION; ELEVATION;
Keywords:
ASYMMETRIC DIMETHYLARGININE; HYPERTENSION; NITRIC OXIDE; NOREPINEPHRINE; SLEEP APNEA; SYMPATHETIC ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Hedner, "DAYTIME WAKING AUTONOMIC FUNCTION AND VASCULAR CONTROL IN OSA", Journal of sleep research, 4, 1995, pp. 171-175

Abstract

This paper deals with the potential role of two blood pressure regulatory systems in the development of hypertension in obstructive deep apnoea (OSA). Beside the acute and long-term sympathoexcitation documented in this disease, there seems to be an impaired endothelium-dependent vascular relaxation. In particular, nitric oxide (NO)-mediated vasodilatation was impaired in patients with OSA. Both these changes act toincrease blood pressure during physiological conditions. However, they may not be determinants for hypertension development in OSA as no differences between normo- and hypertensive patients with OSA were detected, Nevertheless, an altered balance between the vasoconstrictive influence of the sympathoadrenergic system and the vasodilatory action ofNO-dependent vascular relaxation may be of importance in the development of sustained hypertension in OSA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:12:37