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Titolo:
A STUDY OF CYTOKINES IN BURN BLISTER FLUID RELATED TO WOUND-HEALING
Autore:
ONO I; GUNJI H; ZHANG JZ; MARUYAMA K; KANEKO F;
Indirizzi:
FUKUSHIMA MED COLL,DEPT DERMATOL,DIV PLAST & RECONSTRUCT SURG,HIKARIGAOKA 1 FUKUSHIMA 96012 JAPAN
Titolo Testata:
Burns
fascicolo: 5, volume: 21, anno: 1995,
pagine: 352 - 355
SICI:
0305-4179(1995)21:5<352:ASOCIB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
I. Ono et al., "A STUDY OF CYTOKINES IN BURN BLISTER FLUID RELATED TO WOUND-HEALING", Burns, 21(5), 1995, pp. 352-355

Abstract

This report indicates that retention fluid from blisters of partial skin thickness burns, which contains relatively large amounts of cytokines and growth factors, stimulates the wound healing process., Although epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) levels were low, relatively large amounts of cytokines including platelet derived growth factor (PDGF), interleukin (IL-6) and transforming growth factor (TGF) alpha were present and these exercised stimulatory effects on wound healing. TGF beta, which plays an important rolein collagen metabolism and in scar formation, was also detected. Contrary to our expectations, IL-1 alpha and beta, both of which initiate inflammation, were detected at retalively low levels whereas IL-8 levels were rather high. Various cytokines weve shown to coexist in a balanced slate in the retention fluids, suggesting that epithelialization might be regulated via a cytokine network operating on the wound surface. The growth of keratinocytes in culture significantly increased with the addition of 1 per cent or more of blister fluid to the medium.

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Documento generato il 03/12/20 alle ore 21:46:03