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Titolo:
DEAFFERENTATION-INDUCED EXPRESSION OF GAP-43, NCAM AND NILE IN THE ADULT-RAT DORSAL HORN FOLLOWING PRONASE INJECTION OF THE SCIATIC-NERVE
Autore:
LAMOTTE CC; KAPADIA SE; ARSENAULT K; WOLFE M;
Indirizzi:
YALE UNIV,SCH MED,NEUROSURG SECT NEW HAVEN CT 06510
Titolo Testata:
Somatosensory & motor research
fascicolo: 1, volume: 12, anno: 1995,
pagine: 71 - 79
SICI:
0899-0220(1995)12:1<71:DEOGNA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; IMMUNOELECTRON MICROSCOPIC LOCALIZATION; ROOT GANGLION-CELLS; SPINAL-CORD; N-CAM; PERIPHERAL-NERVE; POLYSIALIC ACID; PROTEIN GAP-43; SYSTEM; GLYCOPROTEIN;
Keywords:
PRIMARY AFFERENTS; CELL ADHESION MOLECULES; AXONAL GUIDANCE; PLASTICITY; GUIDANCE FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Lamotte et al., "DEAFFERENTATION-INDUCED EXPRESSION OF GAP-43, NCAM AND NILE IN THE ADULT-RAT DORSAL HORN FOLLOWING PRONASE INJECTION OF THE SCIATIC-NERVE", Somatosensory & motor research, 12(1), 1995, pp. 71-79

Abstract

The expression of growth-associated protein 43 (GAP-43), neural cell adhesion molecule (NCAM), and nerve-growth-factor-inducible large external glycoprotein (NILE) in the adult rat dorsal horn was examined at several survival times after unilateral pronase injection of the sciatic nerve. Pronase injection produces a permanent major loss of sciaticprimary afferents in the dorsal horn, and there is a later sprouting of saphenous afferents into the sciatic territory. Small-diameter myelinated and nonmyelinated saphenous afferents sprout within the superficial dorsal horn, and larger, myelinated afferents sprout within the deep dorsal horn. In the present study, GAP-43 and NCAM immunoreactivity increased in the superficial dorsal horn by 10 days after injection. By 20 days, the increase spread into the deep dorsal horn; NCAM returned to normal after 1-2 months, but GAP-43 persisted up to 4 months. NILE immunoreactivity appeared in laminae I and II by 10 days and increased up to 30 days; by 2 months no NILE remained. NILE never spread into the deeper dorsal horn, regardless of survival time. These data suggest a correlation in the expression of both NCAM and NILE with the sprouting of fine-diameter sprouting afferents in laminae I and II, and of NCAM expression with the sprouting of larger-diameter afferents in the deep dorsal horn. The early appearance of GAP-43, NCAM, and NILE in laminae I and II, and delayed onset of NCAM and GAP-43 in the deeperdorsal horn, may be correlated with the early clearing of degeneratedafferent terminals in laminae I and II and persistence of degeneratedterminals in the deep dorsal horn that occur after primary afferent injury. The expression of GAP-43 beyond that of NCAM and NILE may indicate that once sprouted terminals are guided to their targets, further growth and maturation of the terminals take place, reaching completionby 4 months.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:28:25