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Titolo:
THE EFFECT OF FLUMAZENIL ON CNS OXYGEN-TOXICITY IN THE RAT
Autore:
BITTERMAN N; HALPERN P;
Indirizzi:
ISRAEL NAVAL MED INST,POB 8040 IL-31080 HAIFA ISRAEL ICHILOV TEL AVIV MED CTR,DEPT ANESTHESIOL & CRIT CARE MED TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 3, volume: 17, anno: 1995,
pagine: 169 - 174
SICI:
0379-0355(1995)17:3<169:TEOFOC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RO 15-1788; BENZODIAZEPINE ANTAGONIST; HYPEROXIA; PENTYLENETETRAZOL; SEIZURES; BRAIN; EEG;
Keywords:
HYPERBARIC OXYGEN; HYPEROXIA; BENZODIAZEPINE RECEPTOR; ANEXATE; RO 15-1788;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N. Bitterman e P. Halpern, "THE EFFECT OF FLUMAZENIL ON CNS OXYGEN-TOXICITY IN THE RAT", Methods and findings in experimental and clinical pharmacology, 17(3), 1995, pp. 169-174

Abstract

The toxicity of hyperbaric oxygen in the central nervous system is expressed by generalized tonic-clonic seizures. In the search for drugs effective against these seizures, we tested flumazenil, a benzodiazepine antagonist known to have antiepileptic properties. Ferry rats with chronic cortical electrodes were injected i.p. with one of three dosesof flumazenil (0.2, 2, and 20 mg/kg) or their vehicle, before exposure to 0.5 MPa oxygen. EEG and the spectral analysis of background EEG activity were monitored. The duration of the latent period until the appearance of electrical discharges in the EEG was used as an index oxygen toxicity. Significantly prolongation of the latent period precedingoxygen seizures was noted in the group of rats treated with 0.2 mg/kgflumazenil (p < 0.05 in Tukey test). However, when the dose of flumazenil was increased, the duration of the latent period returned to control values. These diverse effects of flumazenil on the benzodiazepine receptor may account for its complex effects on hyperoxic-induced seizures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 16:45:13