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Titolo:
DISSOCIATION BETWEEN THE ATTENTIONAL EFFECTS OF INFUSIONS OF A BENZODIAZEPINE RECEPTOR AGONIST AND AN INVERSE AGONIST INTO THE BASAL FOREBRAIN
Autore:
HOLLEY LA; TURCHI J; APPLE C; SARTER M;
Indirizzi:
OHIO STATE UNIV,DEPT PSYCHOL,27 TOWNSHEND HALL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT PSYCHOL COLUMBUS OH 43210
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 120, anno: 1995,
pagine: 99 - 108
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-DETECTION THEORY; RAT FRONTAL-CORTEX; NUCLEUS BASALIS; SOMATOSENSORY CORTEX; CHOLINERGIC NEURONS; VIGILANCE; MEMORY; MUSCIMOL; MAGNOCELLULARIS; ACETYLCHOLINE;
Keywords:
BENZODIAZEPINE RECEPTOR; CHLORDIAZEPOXIDE; BETA-CCM; ATTENTION; BASAL FOREBRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Holley et al., "DISSOCIATION BETWEEN THE ATTENTIONAL EFFECTS OF INFUSIONS OF A BENZODIAZEPINE RECEPTOR AGONIST AND AN INVERSE AGONIST INTO THE BASAL FOREBRAIN", Psychopharmacology, 120(1), 1995, pp. 99-108

Abstract

The effects of infusions of the benzodiazepine receptor (BZR) full agonist chlordiazepoxide (CDP) or the full inverse agonist beta-CCM intothe basal forebrain on behavioral vigilance were tested. Vigilance was measured by using a previously characterized task that requires the animals to discriminate between visual signals of variable length and non-signal events. Measures of performance,included hits, misses, correct rejections, false alarms, side bias, and errors of omission. Following the infusion of saline (0.5 mu l/hemisphere), the relative numberof hits varied with signal length. In response to shorter signals, the number of hits decreased over time, indicating a vigilance decrement. Infusions of CDP (20, 40 mu g/hemisphere) initially decreased the relative number of hits in response to shorter signals and, later in thecourse of the test sessions, to longer signals as well. CDP did not affect the relative number of correct rejections. In contrast, infusions of the inverse agonist beta-CCM (1.5, 3.0 mu g/hemisphere) did not affect the relative number of hits but decreased the relative number ofcorrect rejections (i.e., increased the number of false alarms). These data suggest that the basal forebrain mediates the attentional effects of BZR ligands. As systemic or intrabasalis administration of BZR agonists and inverse agonists was previously demonstrated to decrease and augment, respectively, activated cortical acetylcholine (ACh) efflux, their effects on behavioral vigilance are hypothesized to be mediated via their effects on cortical ACh.

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Documento generato il 06/08/20 alle ore 23:56:11