Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ITCH AND INFLAMMATION-INDUCED BY INTRADERMALLY INJECTED INTERLEUKIN-2IN ATOPIC-DERMATITIS PATIENTS AND HEALTHY-SUBJECTS
Autore:
WAHLGREN CF; LINDER MT; HAGERMARK O; SCHEYNIUS A;
Indirizzi:
KAROLINSKA HOSP,DEPT DERMATOL,POB 120 S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT CLIN IMMUNOL S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Archives of dermatological research
fascicolo: 6, volume: 287, anno: 1995,
pagine: 572 - 580
SICI:
0340-3696(1995)287:6<572:IAIBII>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL CLONES; MONOCLONAL-ANTIBODIES; IGE SYNTHESIS; SKIN; PATHOPHYSIOLOGY; LYMPHOCYTES; INVITRO; FIBERS; ECZEMA; GAMMA;
Keywords:
BIOPSY SPECIMENS; CYTOKINES; LYMPHOCYTES; PRURITUS; SPONGIOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Wahlgren et al., "ITCH AND INFLAMMATION-INDUCED BY INTRADERMALLY INJECTED INTERLEUKIN-2IN ATOPIC-DERMATITIS PATIENTS AND HEALTHY-SUBJECTS", Archives of dermatological research, 287(6), 1995, pp. 572-580

Abstract

To explore the pruritogenic and inflammatory effects of cytokines, a single dose of 20 mu g recombinant human interleukin-2 was injected intradermally into eight patients with atopic dermatitis and eight healthy controls, The study was double-blind and randomized with glucose asa negative control, The effects were evaluated by recording local itch and erythema over 72 h and by examining skin biopsies taken at 24 h and 72 h. In patients and controls, interleukin-2 provoked a low-intensity local itch with maximal intensity between 6 h and 48 h and erythema with maximal extension between 12 h and 72 h. In the atopic dermatitis patients, these reactions tended to appear earlier and were less pronounced than in the healthy controls, Interleukin-2 induced dermal mononuclear cell infiltrates consisting mainly of CD3(+) cells. A majority of the T cells were CD4(+). The number of dermal CD25(+), HLA-DR(+) and ICAM-1(+) cells was also increased at the interleukin-2 injection sites, In the epidermis, interleukin-2 induced spongiosis and exocytosis as well as HLA-DR(+) and ICAM-1(+) keratinocytes, The microscopicfindings tended to be more prominent at 72 h than at 24 h in both groups, but with a somewhat slower onset in the atopic dermatitis patients, In conclusion, a single intradermal injection of interleukin-2 induced local itch, erythema, dermal T-cell infiltrates, spongiosis, exocytosis and activation of keratinocytes both in atopic dermatits patients and in healthy controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:07:56