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Titolo:
REEMERGENCE OF GAP-43 IN COCHLEAR NUCLEUS AND SUPERIOR OLIVE FOLLOWING COCHLEAR ABLATION IN THE RAT
Autore:
ILLING RB; HORVATH M;
Indirizzi:
UNIV FREIBURG,DEPT OTORHINOLARYNGOL,MORPHOL BRAIN RES UNIT,KILLIANSTR5 D-79106 FREIBURG GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 194, anno: 1995,
pagine: 9 - 12
SICI:
0304-3940(1995)194:1-2<9:ROGICN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOUND DEPRIVATION; SPINAL-CORD; PROTEIN; BRAIN; EXPRESSION; NEURONS; NERVE;
Keywords:
AUDITORY SYSTEM; AUDITORY DEPRIVATION; COCHLEAR NUCLEUS; SUPERIOR OLIVARY COMPLEX; OLIVOCOCHLEAR BUNDLE; GAP-43; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Illing e M. Horvath, "REEMERGENCE OF GAP-43 IN COCHLEAR NUCLEUS AND SUPERIOR OLIVE FOLLOWING COCHLEAR ABLATION IN THE RAT", Neuroscience letters, 194(1-2), 1995, pp. 9-12

Abstract

The effect of cochlear lesion on the expression of the growth associated protein GAP-43 in superior olive and cochlear nucleus was studied in the rat. In normal development of these auditory brainstem nuclei, GAP-43 immunoreactivity is high perinatally but low 10 days postnatally or thereafter. Removal of one spiral ganglion in grown-up animals caused a substantial re-emergence of GAP-43 immunoreactivity in varicosefibers of the ipsilateral ventral cochlear nucleus and cell bodies ofthe lateral superior olive. These findings suggest that a reactive synaptogenesis takes place in the cochlear nucleus as a consequence of deafening through spiral ganglion loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:41:59