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Titolo:
ENDOTHELIN-1 AND ENDOTHELIN-3 MODULATE DOPAMINERGIC-NEURONS THROUGH DIFFERENT MECHANISMS
Autore:
HORIE K; MORITA A; YOKOGOSHI H;
Indirizzi:
UNIV SHIZUOKA,SCH FOOD & NUTR SCI,NUTR BIOCHEM LAB,52-1 YADA SHIZUOKA422 JAPAN UNIV SHIZUOKA,SCH FOOD & NUTR SCI,NUTR BIOCHEM LAB SHIZUOKA 422 JAPAN
Titolo Testata:
Life sciences
fascicolo: 8, volume: 57, anno: 1995,
pagine: 735 - 741
SICI:
0024-3205(1995)57:8<735:EAEMDT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL SLICES; BINDING-SITES; RAT; RELEASE; BRAIN; RECEPTOR; MICRODIALYSIS; ISOPEPTIDES; PITUITARY; CLONING;
Keywords:
ENDOTHELIN-1; ENDOTHELIN-3; DOPAMINE; GLUTAMATE; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Horie et al., "ENDOTHELIN-1 AND ENDOTHELIN-3 MODULATE DOPAMINERGIC-NEURONS THROUGH DIFFERENT MECHANISMS", Life sciences, 57(8), 1995, pp. 735-741

Abstract

Novel vasoconstrictor peptides, endothelin-1 (ET-1) and endothelin-3 (ET-3), are also known as neuropeptides or neuromodulators. When either ET-1 or ET-3 was administered to the rat striatum via a microinjection needle, the dopamine release from the striatum dose-dependently increased. Pretreatment with a glutamate receptor blocker, glutamate diethyl ester hydrochloride, inhibited the dopamine release induced by ET-3, whereas it further enhanced the dopamine release by ET-1. This suggests that ET-1 directly induces the dopamine release, whereas the action of ET-3 is mediated by glutamate different distributions of endothelin receptors: ET(A) receptors may be present on the dopaminergic neurons, but ET(B) receptors on the glutamatergic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:00:51