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Titolo:
A GENE (DLG2) LOCATED AT 17Q12-Q21 ENCODES A NEW HOMOLOG OF THE DROSOPHILA TUMOR-SUPPRESSOR DLG-A
Autore:
MAZOYER S; GAYTHER SA; NAGAI MA; SMITH SA; DUNNING A; VANRENSBURG EJ; ALBERTSEN H; WHITE R; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,CRC HUMAN CANC GENET RES GRP,LABS BLOCK,HILLS RD CAMBRIDGE CB2 2QP ENGLAND UNIV UTAH,ECCLES INST HUMAN GENET SALT LAKE CITY UT 84112 UNIV UTAH,HOWARD HUGHES MED INST SALT LAKE CITY UT 84112
Titolo Testata:
Genomics
fascicolo: 1, volume: 28, anno: 1995,
pagine: 25 - 31
SICI:
0888-7543(1995)28:1<25:AG(LA1>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE-MEMBRANE PROTEIN; SEPTATE JUNCTIONS; GUANYLATE KINASE; IDENTIFICATION; MOLECULES; CLONING; OVARIAN; REGION; LOCUS; ZO-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Mazoyer et al., "A GENE (DLG2) LOCATED AT 17Q12-Q21 ENCODES A NEW HOMOLOG OF THE DROSOPHILA TUMOR-SUPPRESSOR DLG-A", Genomics, 28(1), 1995, pp. 25-31

Abstract

We have isolated a novel cDNA that maps distal to BRCA1 at 17q12-q21,The total sequence predicts a protein of 576 amino acids with three conserved regions: a 90-amino-acid repeat domain, a SH3 (src homology region 3) motif, and a guanylate kinase domain. These conserved regionsare shared among members of the discs-large family of proteins that include human p55, a membrane protein expressed in erythrocytes, rat PSD-95/SAP90, a synapse protein expressed in brain, Drosophila dig-A, a septate junction protein expressed in various epithelia, and human andmouse ZO-1 and canine ZO-2, two tight junction proteins. dig-A has been shown to act as a tumor suppressor, and the other members may all be involved in signal transduction through specialized membrane domainswith highly organized cytoskeletons and thus are potential tumor suppressors. Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. No evidence for mutation was found, making it unlikely that DLG2 is involved in sporadic breast cancer. (C) 1995 Academic Press, inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:59:01