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Titolo:
THE TER MUTATION FIRST CAUSES PRIMORDIAL GERM-CELL DEFICIENCY IN TER TER MOUSE EMBRYOS AT 8 DAYS OF GESTATION/
Autore:
SAKURAI T; IGUCHI T; MORIWAKI K; NOGUCHI M;
Indirizzi:
SHIZUOKA UNIV,FAC SCI,DEPT BIOL,OHYA 836 SHIZUOKA 422 JAPAN SHIZUOKA UNIV,FAC SCI,DEPT BIOL SHIZUOKA 422 JAPAN YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI YOKOHAMA KANAGAWA 236 JAPAN NATL INST GENET,DEPT CELL GENET MISHIMA SHIZUOKA 411 JAPAN
Titolo Testata:
Development, growth & differentiation
fascicolo: 3, volume: 37, anno: 1995,
pagine: 293 - 302
SICI:
0012-1592(1995)37:3<293:TTMFCP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; C-KIT; GROWTH-FACTOR; STEEL FACTOR; TESTICULAR TERATOMAS; W LOCUS; CULTURE; MICE; PROLIFERATION; EXPRESSION;
Keywords:
CELL PROLIFERATION; MICROSATELLITE DNA; MOUSE CONGENIC STRAIN; PRIMORDIAL GERM CELL DEFICIENCY; TERATOMA (TER) MUTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
T. Sakurai et al., "THE TER MUTATION FIRST CAUSES PRIMORDIAL GERM-CELL DEFICIENCY IN TER TER MOUSE EMBRYOS AT 8 DAYS OF GESTATION/", Development, growth & differentiation, 37(3), 1995, pp. 293-302

Abstract

The ter (teratoma) mutation causes primordial germ cell (PGC) deficiency in ter/ter embryos at 9.5-12.5 days of post-coitum (dpc) in mouse strains 129/Sv-ter and LTXBJ-ter. To study the effects of the fer mutation on the PGC development more precisely, we examined the PGC numberand distribution in 7.5-12.5 dpc embryo of ter congenic C57BL/6J-ter strain using their complete serial sections. The ter genotypes of embryos were identified by the polymerase chain reaction (PCR) polymorphisms of the microsatellite DNA of the Grl-1 locus mapped near the ter locus. Results showed that: (i) the PGC number in ter/ter embryos was similar to those of +/ter and +/+ embryos at 7.5 dpc, and did not increase at 8.0-12.5 dpc, although those of normal littermates did usually; (ii) the PGC migration to genital ridges was never affected in all embryos; and (iii) the ter genotype difference in the PGC numbers was notrecognized between +/ter and +/+ embryos. We concluded that the ter mutation does not affect the PGC appearance around 7.5 dpc, but first causes PGC deficiency around 8.0 dpc at the beginning of their migration and proliferation, suggesting that the normal function of the ter gene may be essential for the proliferation or survival mechanisms of PGC.

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Documento generato il 06/07/20 alle ore 08:55:47