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Titolo:
DESTRUCTION OF THE EPITHELIAL ANCHORING SYSTEM IN LICHEN-PLANUS
Autore:
HAAPALAINEN T; OKSALA O; KALLIOINEN M; OIKARINEN A; LARJAVA H; SALO T;
Indirizzi:
UNIV OULU,INST DENT,DEPT ORAL & MAXILLOFACIAL SURG,AAPISTIE 3 SF-90220 OULU FINLAND UNIV OULU,INST DENT,DEPT ORAL & MAXILLOFACIAL SURG SF-90220 OULU FINLAND UNIV OULU,DEPT PATHOL OULU FINLAND UNIV OULU,DEPT DERMATOL SF-90220 OULU FINLAND UNIV TURKU,DEPT PERIODONTOL TURKU FINLAND UNIV BRITISH COLUMBIA,DEPT CLIN DENT SCI,DIV PERIODONT VANCOUVER BC CANADA
Titolo Testata:
Journal of investigative dermatology
fascicolo: 1, volume: 105, anno: 1995,
pagine: 100 - 103
SICI:
0022-202X(1995)105:1<100:DOTEAS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE ADHESION; VII COLLAGEN; MONOCLONAL-ANTIBODY; HEMIDESMOSOMES; ALPHA-6-BETA-4; KERATINOCYTES; INTEGRIN-ALPHA-6-BETA-4; EXPRESSION; FILAMENTS; INTEGRINS;
Keywords:
TYPE VII COLLAGEN; ALPHA-6-BETA-4 INTEGRIN RECEPTOR; KALININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Haapalainen et al., "DESTRUCTION OF THE EPITHELIAL ANCHORING SYSTEM IN LICHEN-PLANUS", Journal of investigative dermatology, 105(1), 1995, pp. 100-103

Abstract

To find out whether the epithelial anchoring system shows any alterations in lichen planus, we examined the distribution of type VII collagen, alpha 6 beta 4 integrin, and kalinin in lesions of lichen planus, These molecules were chosen because they are structural components of anchoring fibrils, hemidesmosome-associated complexes, and anchoring filaments, The localization of type VII collagen in lichen planus was strikingly different from that in nonaffected mucosa or dermis or in other mucocutaneous lesions, In the normal mucosa, type VII collagen waslocalized only at the basement membrane zone, In lichen planus, type vn collagen was present not only in the basement membrane area but also in streaked patterns deep in the connective tissue, The hemidesmosome-associated complex, alpha 6 beta 4 integrin, was localized at the basal aspect of basal epithelial cells of nonaffected sites, but was diffuse and discontinuous in lichen planus lesions. Most of the basal keratinocytes, however, stained for this integrin, Kalinin staining was discontinuous in lichen planus lesions, Often, finger-like projections of kalinin staining were found protruding into the connective tissue stroma, Kalinin was localized at the basement membrane zone of the nonaffected tissue and other mucocutaneous lesions, These results indicatethat in cutaneous and mucosal lichen planus, the epithelial anchoringsystem is disturbed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:13:57