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Titolo:
OXYTOCIN RECEPTOR MESSENGER-RNA EXPRESSION IN THE VENTROMEDIAL HYPOTHALAMUS DURING THE ESTROUS-CYCLE
Autore:
BALE TL; DORSA DM; JOHNSTON CA;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL & PSYCHIAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT PHARMACOL & PSYCHIAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT BEHAV SCI SEATTLE WA 98195 UNIV MONTANA,SCH PHARM & ALLIED HLTH SCI,DEPT PHARMACEUT SCI MISSOULAMT 59812
Titolo Testata:
The Journal of neuroscience
fascicolo: 7, volume: 15, anno: 1995,
parte:, 1
pagine: 5058 - 5064
SICI:
0270-6474(1995)15:7<5058:ORMEIT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT MICROSCOPIC AUTORADIOGRAPHY; BINDING-SITES; RAT-BRAIN; NEUROHYPOPHYSEAL HORMONES; LORDOSIS BEHAVIOR; MATERNAL-BEHAVIOR; FEMALE RATS; INDUCED FACILITATION; SEXUAL RECEPTIVITY; HUMAN-MEMORY;
Keywords:
OXYTOCIN RECEPTOR MESSENGER-RNA; IN SITU HYBRIDIZATION; VENTROMEDIAL HYPOTHALAMUS; ESTROGEN; PROGESTERONE; ESTROUS CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Bale et al., "OXYTOCIN RECEPTOR MESSENGER-RNA EXPRESSION IN THE VENTROMEDIAL HYPOTHALAMUS DURING THE ESTROUS-CYCLE", The Journal of neuroscience, 15(7), 1995, pp. 5058-5064

Abstract

Changes in OR mRNA expression in the ventromedial hypothalamus (VMH) in relation to the estrous cycle were measured by In situ hybridization with a rat oxytocin receptor (OR) probe. Binding studies have localized ORs to various brain regions, and have detected a high density of receptors in the VMH, a nucleus containing large numbers of estrogen responsive neurons. Previous studies in this lab have reported a significant increase in OR mRNA expression in the VMH in ovariectomized ratstreated with estrogen. The present study was designed to determine whether changes in steroid hormone levels across the estrous cycle result in induction of OR mRNA expression. Autoradiographic studies revealed differences in OR mRNA expression in the rostral and caudal as well as medial and lateral aspects of the VMH. OR mRNA levels were highest in the caudal portion of the vIVMH on the afternoon (16:00 hr) of proestrus. The rostral region exhibited a high level of expression in the ventrolateral region of the VMH on the morning (9:00 hr) of proestrus and in the dorsomedial region of the VMH on the afternoon of proestrus. Little or no OR mRNA expression was evident in the rostral or caudalVMH on the morning or evening of diestrus. These results support previous findings which showed a regulation of OR binding by gonadal steroids and suggest that this may be due to altered expression of the OR gene. These effects suggest a possible role of ORs in the oxytocin stimulated release of luteinizing hormone.

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Documento generato il 31/03/20 alle ore 05:12:59