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Titolo:
BIOLOGICAL IMPLICATIONS OF ESTROGEN AND ANDROGEN EFFECTS ON ANDROGEN RECEPTOR AND ITS MESSENGER-RNA LEVELS IN HUMAN UTERINE ENDOMETRIUM
Autore:
FUJIMOTO J; NISHIGAKI M; HORI M; ICHIGO S; ITOH T; TAMAYA T;
Indirizzi:
GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,40 TSUKASA MACHI GIFU 500 JAPAN
Titolo Testata:
Gynecological endocrinology
fascicolo: 2, volume: 9, anno: 1995,
pagine: 149 - 155
SICI:
0951-3590(1995)9:2<149:BIOEAA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
ANDROGEN RECEPTOR; ANDROGEN RECEPTOR MESSENGER-RNA; ESTROGEN AND ANDROGEN EFFECTS; UTERINE ENDOMETRIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J. Fujimoto et al., "BIOLOGICAL IMPLICATIONS OF ESTROGEN AND ANDROGEN EFFECTS ON ANDROGEN RECEPTOR AND ITS MESSENGER-RNA LEVELS IN HUMAN UTERINE ENDOMETRIUM", Gynecological endocrinology, 9(2), 1995, pp. 149-155

Abstract

It has been shown that some effects of testosterone are different from those of its 5 alpha-reduced metabolite, dihydrotestosterone. Briefly, activities of testosterone might be related to cellular differentiation, whereas dihydrotestosterone acts on cellular proliferation. The number of testosterone binding sires in the uterine endometrium was increased by estradiol dipropionate, and this increase was down-regulated by testosterone cypionate. Dihydrotestosterone-specific binding sites in the endometrium were not modulated by estradiol dipropionate and testosterone cypionate. The dissociation constants of the bindings sites for testosterone and dihydrotestosterone were not altered by these steroids. Estradiol dipropionate with or without testosterone cypionate induced androgen receptor mRNA expression in the endometrium. In conclusion, testosterone might predominantly affect cellular differentiation in the endometrium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 02:48:11