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Titolo:
INTERACTIONS BETWEEN ENDOTHELIAL MEDIATORS
Autore:
GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,INST PHARMACOL,16 GRZEGORZECKA PL-31531 KRAKOW POLAND
Titolo Testata:
Pharmacology & toxicology
fascicolo: 1, volume: 77, anno: 1995,
pagine: 1 - 9
SICI:
0901-9928(1995)77:1<1:IBEM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TISSUE PLASMINOGEN-ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; HIGH-DENSITY-LIPOPROTEIN; PERIPHERAL ARTERIAL-DISEASE; VASCULAR SMOOTH-MUSCLE; MACROPHAGE CELL-LINE; RELAXING FACTOR; L-ARGININE; DEPENDENT RELAXATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
116
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Gryglewski, "INTERACTIONS BETWEEN ENDOTHELIAL MEDIATORS", Pharmacology & toxicology, 77(1), 1995, pp. 1-9

Abstract

Prostacyclin, nitric oxide and tissue plasminogen activator constitute a prominent triad of endothelial mediators. Prostacyclin is responsible mainly for maintaining vascular thromboresistance against plateletclumps, inhibits proliferation of vascular smooth muscle and modulates cholesterol turnover, tissue plasminogen activator is a fibrinolyticagent and nitric oxide controls vascular tone and structure. Receptoragonists such as acetylcholine, kinins, endothelins or adenosine diphosphate evoke a coupled release of mediators from endothelial cells. Prostacyclin and nitric oxide synergize in their antiplatelet, fibrinolytic and cardioprotective, but not in their hypotensive actions. Prostacyclin, but not nitric oxide, prevents paradox thrombogenic effects of tissue plasminogen activator. Filogenetically, prostacyclin and tissue plasminogen activator are younger brothers of nitric oxide from which they take over and perfect regulatory properties in circulation. Further studies on interactions of endothelial mediators may lead to a better understanding of mechanisms of thrombosis, atherogenesis, diabetic angiopathies, endotoxic shock and arterial hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:42:17