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Titolo:
FLECAINIDE INHIBITS THE TRANSIENT OUTWARD CURRENT IN ATRIAL MYOCYTES ISOLATED FROM THE RABBIT HEART
Autore:
YAMASHITA T; NAKAJIMA T; HAMADA E; HAZAMA H; OMATA M; KURACHI Y;
Indirizzi:
OSAKA UNIV,FAC MED,DEPT PHARMACOL 2,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,FAC MED,DEPT PHARMACOL 2 SUITA OSAKA 565 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 2 TOKYO 113 JAPAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 274, anno: 1995,
pagine: 315 - 321
SICI:
0022-3565(1995)274:1<315:FITTOC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC PURKINJE-FIBERS; GUINEA-PIG; RATE-DEPENDENCE; ANTIARRHYTHMIC DRUGS; ACTION-POTENTIALS; CELLS; REFRACTORINESS; FIBRILLATION; QUINIDINE; REPOLARIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamashita et al., "FLECAINIDE INHIBITS THE TRANSIENT OUTWARD CURRENT IN ATRIAL MYOCYTES ISOLATED FROM THE RABBIT HEART", The Journal of pharmacology and experimental therapeutics, 274(1), 1995, pp. 315-321

Abstract

We examined the effects of flecainide, a class Ic antiarrhythmic agent, on membrane currents in single rabbit atrial myocytes, using the tight-seal whole cell voltage-clamp technique. Under the current-clamp condition, flecainide (1-100 mu M) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential. In the presence of 4-aminopyridine, however, the drug affected the atrial action potential duration differently than it did in the absence of 4-aminopyridine: it shortened the early phase and only slightly lengthened the late phase of the atrial action potential. Under the voltage-clamp condition, flecainide suppressed the 4-amino-pyridine-sensitive, Ca++-insensitive transient outward current in a concentration-dependent fashion (the concentration for the half-maximal effect was similar to 17 mu M). The drug also slightly inhibited the voltage-dependent L-type Catt current and delayed outward K+ current. Flecainide apparently accelerated the inactivation time course of the transient outward current but did not affect the voltage-dependence of its steady-state inactivation. These actions of flecainide on the transient outward current could be described by a voltage-dependent first-order interaction of the drug with the channel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:58:12