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Titolo:
ACUTE LIVER-FAILURE FOLLOWING ACETAMINOPH EN INGESTION - IS PROTRACTED N-ACETYLCYSTEINE ADMINISTRATION USEFUL
Autore:
REY C; AJZENBERG N; TCHERNIA G; ALVIN P; DREYFUS M;
Indirizzi:
HOP BICETRE,SERV MED ADOLESCENTS,78 RUE GEN LECLERC F-94275 LE KREMLIN BICETR FRANCE HOP BICETRE,HEMATOL LAB F-94275 LE KREMLIN BICETR FRANCE
Titolo Testata:
Archives de pediatrie
fascicolo: 7, volume: 2, anno: 1995,
pagine: 662 - 665
SICI:
0929-693X(1995)2:7<662:ALFAEI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
FRE
Soggetto:
FULMINANT HEPATIC-FAILURE; PARACETAMOL OVERDOSE; TOXICITY;
Keywords:
ACETAMINOPHEN; POISONING; HEPATIC ENCEPHALOPATHY; HEPATITIS, TOXIC; TRANSPLANTATION; GLUTATHIONE; CHELATING AGENTS; ANTIDOTES; CHILD; ADOLESCENT MEDICINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
C. Rey et al., "ACUTE LIVER-FAILURE FOLLOWING ACETAMINOPH EN INGESTION - IS PROTRACTED N-ACETYLCYSTEINE ADMINISTRATION USEFUL", Archives de pediatrie, 2(7), 1995, pp. 662-665

Abstract

Background. - Some cases of paracetamol-induced acute hepatic failuremay require liver transplantation but the present shortage of graft urges the search for an alternate therapeutic approach. Case report. - A 17 year-old girl was admitted for sleepingness and vomiting after about 15 hours of voluntary brit denied absorption of paracetamol. Plasma paracetamol concentration was 120 mg/l; factors VII + X level were 55% and factor V 106%. The patient was given IV N-acetylcysteine, 150 mg/kg/30 min, then 50 mg/kg/4 hours. Further decrease in facteur VII level led to pursue administration of N-acetylcysteine (total dose: 350 mg/kg/2 hours). While indication of liver transplantation was considered, clinical and laboratory findings definitely improved Conclusions. - N-acetylcysteine may be effective even if administered late. Repeated determination of factor VII could be a goad means for managing such a severe condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:11:56