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Titolo:
GLUCOSE ENHANCEMENT OF SCOPOLAMINE-INDUCED INCREASE OF HIPPOCAMPAL HIGH-AFFINITY CHOLINE UPTAKE IN MICE - RELATION TO PLASMA-GLUCOSE LEVELS
Autore:
MICHEAU J; MESSIER C; JAFFARD R;
Indirizzi:
UNIV BORDEAUX 1,NEUROSCI COMPORTEMENTALES & COGNIT LAB,CNRS,URA 339,AVE FAC F-33405 TALENCE FRANCE UNIV OTTAWA,SCH PSYCHOL OTTAWA ON K1N 6N5 CANADA
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 685, anno: 1995,
pagine: 99 - 104
SICI:
0006-8993(1995)685:1-2<99:GEOSIO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; RAT CORPUS STRIATUM; ACETYLCHOLINE SYNTHESIS; BRAIN ACETYLCHOLINE; EXTRACELLULAR ACETYLCHOLINE; ANTICHOLINERGIC DRUGS; INVIVO MICRODIALYSIS; INDUCED DEFICITS; SENILE DEMENTIA; ELDERLY HUMANS;
Keywords:
GLUCOSE; SCOPOLAMINE; CHOLINERGIC SEPTOHIPPOCAMPAL SYSTEM; HIGH-AFFINITY CHOLINE UPTAKE; MEMORY; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J. Micheau et al., "GLUCOSE ENHANCEMENT OF SCOPOLAMINE-INDUCED INCREASE OF HIPPOCAMPAL HIGH-AFFINITY CHOLINE UPTAKE IN MICE - RELATION TO PLASMA-GLUCOSE LEVELS", Brain research, 685(1-2), 1995, pp. 99-104

Abstract

The administration of glucose has been shown to improve memory for various learning tasks in rodents. In humans, glucose also increases declarative memory performance in elderly people and in some patients with mild Alzheimer's disease. One of the possible physiological bases for the effect of glucose on memory processes is a facilitation of cholinergic function through increased synthesis. In support of this hypothesis, glucose was shown to attenuate the amnesia induced by scopolamine and, in similar conditions, glucose increased extracellular levels of acetylcholine following a scopolamine injection. To further examine the interaction between glucose and cholinergic function, the present experiment measured the effects of combined injections of glucose and scopolamine on hippocampal sodium-dependent high-affinity choline uptake, an indirect index of cholinergic activity. Results showed that theinjection of 3 g/kg glucose enhanced the increase in high affinity choline uptake in hippocampal synaptosomes produced by scopolamine. A regression analysis revealed the existence of a positive correlation between plasma blood glucose level and hippocampal choline uptake particularly in the animals receiving a combined injection of scopolamine andglucose. These data further support the hypothesis that glucose administration can facilitate acetylcholine synthesis under certain conditions and that this action could explain how glucose attenuates scopolamine-induced amnesia.

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Documento generato il 30/11/20 alle ore 15:10:28