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Titolo:
RAPID DEVELOPMENT OF DISSEMINATED SUPERFICIAL POROKERATOSIS AFTER TRANSPLANT INDUCTION THERAPY
Autore:
FIELDS LL; WHITE CR; MAZIARZ RT;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT MED,3181 SW SAM JACKSON PK RD PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MED PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT DERMATOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT PATHOL PORTLAND OR 97201 VET AFFAIRS MED CTR,DERMATOL SERV PORTLAND OR 97201 VET AFFAIRS MED CTR,DEPT MED PORTLAND OR 97201
Titolo Testata:
Bone marrow transplantation
fascicolo: 6, volume: 15, anno: 1995,
pagine: 993 - 995
SICI:
0268-3369(1995)15:6<993:RDODSP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOSUPPRESSION; CELLS;
Keywords:
RAPID; DISSEMINATED; SUPERFICIAL POROKERATOSIS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
L.L. Fields et al., "RAPID DEVELOPMENT OF DISSEMINATED SUPERFICIAL POROKERATOSIS AFTER TRANSPLANT INDUCTION THERAPY", Bone marrow transplantation, 15(6), 1995, pp. 993-995

Abstract

Disseminated superficial actinic porokeratosis (DSAP) is a cutaneous disorder, usually inherited in an autosomal dominant fashion, characterized by numerous annular papules with subtle raised hyperkeratotic borders and slightly atrophic centers. While the precise pathophysiologic mechanisms underlying the development of DSAP are unknown, one hypothesis is multifocal expansion of atypical clones of keratinocytes, perhaps unmasked by actinic damage, as implied by its name. Although primarily of cosmetic concern, there is an increased risk of squamous cellcarcinoma of the skin developing within DSAP lesions, which often show histologic keratinocytic atypia centrally. Immunosuppression, which is a significant risk factor for secondary malignancies including cutaneous squamous cell carcinoma, is also a well-documented precipitant of porokeratosis. We report a 62-year-old man who developed DSAP in a widely and rapidly progressive manner within days of receiving total body radiation and high-dose induction chemotherapy as planned preparative therapy for an autologous peripheral blood stem cell transplant forrelapsed high grade lymphoma. Our patient's eruption of DSAP highlights a little recognized cutaneous manifestation of aggressive bone marrow transplant induction therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:42:07