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Titolo:
IMMUNOCYTOCHEMICAL DETECTION OF TUMOR-CELLS IN BONE-MARROW AND PERIPHERAL-BLOOD STEM-CELL COLLECTIONS FROM PATIENTS WITH OVARIAN-CANCER
Autore:
ROSS AA; MILLER GW; MOSS TJ; KAHN DG; WARNER NE; SWEET DL; LOUIE KG; SCHNEIDERMANN E; PECORA AL; MEAGHER RC; HERZIG RH; COLLINS RH; FAY JW;
Indirizzi:
BIS LABS,19231 VICTORY BLVD,SUITE 12 RESEDA CA 91335 CEDARS SINAI MED CTR LOS ANGELES CA 90048 BAYLOR UNIV,MED CTR DALLAS TX 00000 WASHINGTON UNIV,MED CTR ST LOUIS MO 00000 HINSDALE HOSP HINSDALE IL 00000 HACKENSACK MED CTR HACKENSACK NJ 07604 UNIV CINCINNATI,MED CTR,HOXWORTH BLOOD CTR CINCINNATI OH 45267
Titolo Testata:
Bone marrow transplantation
fascicolo: 6, volume: 15, anno: 1995,
pagine: 929 - 933
SICI:
0268-3369(1995)15:6<929:IDOTIB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; TRANSPLANTATION; CARCINOMAS; RELAPSE;
Keywords:
TUMOR MICROMETASTASES; OVARIAN CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Ross et al., "IMMUNOCYTOCHEMICAL DETECTION OF TUMOR-CELLS IN BONE-MARROW AND PERIPHERAL-BLOOD STEM-CELL COLLECTIONS FROM PATIENTS WITH OVARIAN-CANCER", Bone marrow transplantation, 15(6), 1995, pp. 929-933

Abstract

High-dose chemotherapy (HDC) followed by autologous hematopoietic reconstitution is an experimental treatment option for patients with epithelial ovarian cancer. However, the incidence of occult ovarian tumor cell involvement in autologous bone marrow (BM) or peripheral blood stem cell (PBSC) autografts has not been widely investigated. We used a highly sensitive immunocytochemical (ICC) procedure that detects occult bloodborne tumor micrometastases. We analyzed 24 BM specimens (15 obtained during therapy and 9 harvest samples) and seven PBSC specimens from 22 patients with ovarian cancer. Overall, ICC analysis detected immunostained tumor cells in 10 of 23 evaluable BM specimens (43%) from9 of 19 patients (47%). One of 9 (11%) harvest samples contained tumor cells. Only one of the 10 ICC-positive BM specimens had tumor cells detected by routine histopathological analysis. ICC-detectable tumor cells were cleared from the marrow of two patients during chemotherapy. None of the seven PBSC specimens contained tumor cells. We conclude that ovarian cancer micrometastases have the potential to contaminate BM, as is also the case in patients with other epithelial malignancies. In the limited number of specimens analyzed, PBSC harvests appeared to provide a less tumor-contaminated source of hematopoietic stem cellsfor autologous transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:39:37