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Titolo:
HIGH-FREQUENCY FATIGUE IN RAT SKELETAL-MUSCLE - ROLE OF EXTRACELLULARION CONCENTRATIONS
Autore:
CAIRNS SP; DULHUNTY AF;
Indirizzi:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,MUSCLE RES GRP,POB 334 CANBERRA ACT 2601 AUSTRALIA AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,MUSCLE RES GRP CANBERRA ACT 2601 AUSTRALIA
Titolo Testata:
Muscle & nerve
fascicolo: 8, volume: 18, anno: 1995,
pagine: 890 - 898
SICI:
0148-639X(1995)18:8<890:HFIRS->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TWITCH MUSCLE; STIMULATED CONTRACTIONS; EXCITATION-FREQUENCY; STERNOMASTOID MUSCLE; FIBERS; FROG; RESPONSES; VOLUNTARY; POTASSIUM; XENOPUS;
Keywords:
HIGH-FREQUENCY FATIGUE; RAT SKELETAL MUSCLE; EXTRACELLULAR ION CONCENTRATIONS; ACTION POTENTIALS; TRANSVERSE TUBULE SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Cairns e A.F. Dulhunty, "HIGH-FREQUENCY FATIGUE IN RAT SKELETAL-MUSCLE - ROLE OF EXTRACELLULARION CONCENTRATIONS", Muscle & nerve, 18(8), 1995, pp. 890-898

Abstract

High-frequency fatigue (HFF), the decline of force during continuous tetanic stimulation (lasting 4-40 s), was studied in isolated bundles of rat skeletal muscle fibers. HFF was slower in slow-twitch soleus fibers than in fast-twitch red or white sternomastoid fibers; denervation accelerated fatigue in soleus. Maximal 200-mmol/L potassium contractures of normal amplitude were induced in fatigued fibers, suggesting that crossbridge cycling and the voltage activation of excitation-contraction coupling could still occur maximally, but that activation by action potentials was impaired. An increase in [Na+](o) slowed HFF, while a small increase in [K+](o) or reduction in [Cl-](o) accelerated HFF. Increasing the tetanic stimulation frequency exacerbated fatigue. Recovery from HFF proceeded rapidly since force increased markedly within a few seconds when stimulation ceased, These results support the hypothesis that a redistribution of Na+, K+, and Cl- across the transverse tubular membranes during repeated action potential activity induces fatigue by reducing the amplitude and conduction of action potentials. (C) 1995 John Wiley and Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:02:51