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Titolo:
IMMUNOGENICITY OF THE SHIGELLA-FLEXNERI SEROTYPE-Y (SFL124) VACCINE STRAIN EXPRESSING CLONED GLUCOSYL TRANSFERASE GENE OF CONVERTING BACTERIOPHAGE-SFX
Autore:
HUAN PT; TAYLOR R; LINDBERG AA; VERMA NK;
Indirizzi:
AUSTRALIAN NATL UNIV,FAC SCI,SCH LIFE SCI,DIV BIOCHEM & MOLEC BIOL,GPO BOX 4 CANBERRA ACT 0200 AUSTRALIA AUSTRALIAN NATL UNIV,FAC SCI,SCH LIFE SCI,DIV BIOCHEM & MOLEC BIOL CANBERRA ACT 0200 AUSTRALIA KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN BACTERIOL S-14186 HUDDINGE SWEDEN
Titolo Testata:
Microbiology and immunology
fascicolo: 7, volume: 39, anno: 1995,
pagine: 467 - 472
SICI:
0385-5600(1995)39:7<467:IOTSS(>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCODING GENE; O-ANTIGENS; DIARRHEA; BINDING;
Keywords:
SHIGELLA FLEXNERI; BACTERIOPHAGE-SFX; PHAGE CONVERSION; GLUCOSYL TRANSFERASE GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P.T. Huan et al., "IMMUNOGENICITY OF THE SHIGELLA-FLEXNERI SEROTYPE-Y (SFL124) VACCINE STRAIN EXPRESSING CLONED GLUCOSYL TRANSFERASE GENE OF CONVERTING BACTERIOPHAGE-SFX", Microbiology and immunology, 39(7), 1995, pp. 467-472

Abstract

The glucosyl transferase gene (gtr) from bacteriophage phage X (SfX) caused partial conversion of serotype Y (group antigen 3, 4) to X (group antigen 7, 8) when introduced into a candidate vaccine strain of Shigella flexneri serotype Y (SFL124). The gtr gene caused conversion ofO-antigens but did not eliminate the adsorption of the corresponding phage SfX. The hybrid strain expressing both group antigens 7, 8 and 3, 4 showed 75% protection when immunized guinea pigs were challenged with a wild-type S. flexneri serotype X strain. No protection was observed against serotype Y challenge, although group antigen 3, 4 was detected in the LPS of the hybrid strain. This suggests the importance of O-antigen immunity in the host defense against shigellosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:26:31