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Titolo:
EFFECTS OF CISAPRIDE ON ULCER FORMATION AND GASTRIC-SECRETION IN RATS- COMPARISON WITH RANITIDINE AND OMEPRAZOL
Autore:
DELALASTRA CA; MARTIN MJ; LACASA MC; LOPEZ A; MOTILVA V;
Indirizzi:
UNIV SEVILLA,FAC FARM,FARMACOL LAB,DEPT FARM & TECNOL FARMACEUT,C PROF GARCIA GONZALEZ S-N E-41012 SEVILLE SPAIN
Titolo Testata:
General pharmacology
fascicolo: 8, volume: 27, anno: 1996,
pagine: 1415 - 1420
SICI:
0306-3623(1996)27:8<1415:EOCOUF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL MOTILITY DISORDERS; 5-HT(3) RECEPTOR ANTAGONISTS; COLD-RESTRAINT STRESS; PROKINETIC AGENT; ZINC ACEXAMATE; PHARMACOLOGY; REFLUX; METOCLOPRAMIDE; RESISTANCE; PREVENTION;
Keywords:
CISAPRIDE; GASTRIC ULCER; GASTRIC SECRETION; MUCUS SECRETION; MORPHOMETRIC STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Delalastra et al., "EFFECTS OF CISAPRIDE ON ULCER FORMATION AND GASTRIC-SECRETION IN RATS- COMPARISON WITH RANITIDINE AND OMEPRAZOL", General pharmacology, 27(8), 1996, pp. 1415-1420

Abstract

1. The antiulcerogenic effects of cisapride, a potent benzamide-stimulating gastrointestinal motility agent, were studied on cold-restraintand pylorus-ligated gastric ulcers. Acidity, composition of gastric secretion, and quantitative and qualitative changes on mucus glycoprotein content were also determined. These effects were compared with those of ranitidine (50 mg/kg) and omeprazol (10 mg/kg). 2. Oral cisapride(10-100 mg/kg) dose-relatedly and significantly (P<0.01, P<0.05) decreased the severity of the lesions induced by cold-restraint stress. Instressed rats, cisapride increased the amount of mucus secretion and markedly enhanced the glycoprotein content. Morphometric evaluation ofmucus secretion revealed a significant increase in both the PAS area (neutral glycoproteins) and Alcian blue area (sulfated glycoproteins).3. In 4 h pyloric-ligated animals, cisapride (10-100 mg/kg) showed a significant reduction in the number and severity of ulcers (P<0.01) and histamine concentration (P<0.01, P<0.001). In addition, at the highest doses (50-100 mg/kg), cisapride produced a significant decrease in acidity; however, it did not alter the gastric volume secretion or pepsin concentrations. 4. These results suggest that cisapride shows antiulcerogenic effects which could possibly be explained through antisecretory and cytoprotective mechanisms involving an enhancement of cuality and production of gastric mucus. Copyright (C) 1996 Elsevier ScienceInc.

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Documento generato il 02/12/20 alle ore 05:13:52