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Titolo:
THE IDENTIFICATION AND MANAGEMENT OF DRUG-INDUCED AKATHISIA
Autore:
SACHDEV P;
Indirizzi:
PRINCE HENRY HOSP,INST NEUROPSYCHIAT,POB 233 MATRAVILLE NSW 2036 AUSTRALIA UNIV NEW S WALES,SCH PSYCHIAT SYDNEY NSW AUSTRALIA PRINCE HENRY HOSP,INST NEUROPSYCHIAT SYDNEY NSW AUSTRALIA
Titolo Testata:
CNS DRUGS
fascicolo: 1, volume: 4, anno: 1995,
pagine: 28 - 46
SICI:
1172-7047(1995)4:1<28:TIAMOD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; INDUCED MOVEMENT-DISORDERS; TARDIVE AKATHISIA; CLINICAL CHARACTERISTICS; UNILATERAL AKATHISIA; DOUBLE-BLIND; PROPRANOLOL; DYSKINESIA; FLUOXETINE; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
93
Recensione:
Indirizzi per estratti:
Citazione:
P. Sachdev, "THE IDENTIFICATION AND MANAGEMENT OF DRUG-INDUCED AKATHISIA", CNS DRUGS, 4(1), 1995, pp. 28-46

Abstract

Akathisia is a common and clinically important adverse effect of antipsychotic and some other psychotropic drugs, which has until recently been neglected by researchers and clinicians. It manifests as a subjective feeling of restlessness (particularly referable to the lower limbs) and a compulsion to move, and is objectively characterised by limb and body movements and behavioural features. The association of akathisia with antipsychotic drugs is complex. Sub types of akathisia (acute, chronic, tardive and withdrawal akathisia) are now recognised, whichresemble each other phenomenologically, but may have different pharmacological profiles in terms of treatment and, possibly, aetiology. Theclinical diagnosis of akathisia may be difficult, as it has to be distinguished from psychotic agitation, anxiety and other syndromes. However, there are some distinctive features that assist in the identification of akathisia, especially if there is a high index of suspicion. The treatment of akathisia is not always satisfactory, and strategies to prevent or minimise its occurrence should prevail. The 2 classes of drugs most commonly used in the treatment of acute akathisia are anticholinergics and P-adrenoceptor blockers, but other drugs may play a minor role. The treatment of tardive akathisia is insufficiently researched and complicated by its overlap with tardive dyskinesia. However, catecholamine depleters, anticholinergic drugs, anti-adrenergic drugs and clozapine may have a role in the treatment of this subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:18:04