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Titolo:
PREFERENTIAL ACTIVATION AND EXPANSION OF HUMAN PERIPHERAL-BLOOD GAMMA-DELTA T-CELLS IN RESPONSE TO TOXOPLASMA GONDII IN VITRO AND THEIR CYTOKINE PRODUCTION AND CYTOTOXIC ACTIVITY AGAINST T-GONDII-INFECTED CELLS
Autore:
SUBAUSTE CS; CHUNG JY; DO D; KONIARIS AH; HUNTER CA; MONTOYA JG; PORCELLI S; REMINGTON JS;
Indirizzi:
PALO ALTO MED FDN,RES INST,DEPT IMMUNOL & INFECT DIS,860 BRYANT ST PALO ALTO CA 94301 STANFORD UNIV,SCH MED,DEPT MED,DIV INFECT DIS STANFORD CA 94305 HARVARD UNIV,SCH MED,DEPT RHEUMATOL & IMMUNOL BOSTON MA 02115
Titolo Testata:
The Journal of clinical investigation
fascicolo: 1, volume: 96, anno: 1995,
pagine: 610 - 619
SICI:
0021-9738(1995)96:1<610:PAAEOH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEIN; LIVE MYCOBACTERIUM-TUBERCULOSIS; CD8+ LYMPHOCYTES-T; PLASMODIUM-FALCIPARUM; RHEUMATOID-ARTHRITIS; INTERFERON-GAMMA; PROTECTIVE ROLE; ANTIGEN; RECEPTOR; CD4+;
Keywords:
T CELL RECEPTOR; MAJOR HISTOCOMPATIBILITY COMPLEX; INTERFERON-GAMMA; INTERLEUKIN-2; TUMOR NECROSIS FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Subauste et al., "PREFERENTIAL ACTIVATION AND EXPANSION OF HUMAN PERIPHERAL-BLOOD GAMMA-DELTA T-CELLS IN RESPONSE TO TOXOPLASMA GONDII IN VITRO AND THEIR CYTOKINE PRODUCTION AND CYTOTOXIC ACTIVITY AGAINST T-GONDII-INFECTED CELLS", The Journal of clinical investigation, 96(1), 1995, pp. 610-619

Abstract

Studies were conducted to determine if gamma delta T cells participate in the immune response to Toxoplasma gondii. Preferential expansion of human gamma delta T cells occurred when peripheral blood T cells from either T. gondii-seronegative or seropositive individuals were incubated with autologous PBMC infected with the parasite. That gamma delta T cells proliferated after incubation with infected cells was confirmed using purified of gamma delta T cells. These T. gondii-induced gamma delta T cell responses did not require prior exposure to the parasite since T cells obtained from umbilical cord blood from seronegative newborns also exhibited preferential expansion of gamma delta T cells. Cytofluorometric analysis of T cells obtained from either umbilical cord blood or peripheral blood from adults revealed that V gamma 9(+) and V delta 2(+) gamma delta T cells responded to stimulation with infected cells. Preferential expansion of gamma delta T cells was not restricted by polymorphic determinants of MHC molecules. PBMC that had internalized killed parasites but not PBMC incubated with T. gondii lysate antigens also stimulated preferential expansion and activation of gamma delta T cells as assessed by expression of CD25 and HLA-DR molecules. V gamma 9(+)V delta 2(+)gamma delta T cells were cytotoxic for T. gondii-infected cells in an MHC-unrestricted manner, and produced IFN-gamma, IL-2, TNF-alpha, but not IL-4 when incubated with cells infected with the parasite. These results suggest that rapid induction of a remarkable primary gamma delta T cell response may be important in the early protective immune response to T. gondii.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:47:10